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胰岛素样生长因子1受体及其通路在原发性肝癌诊治中的研究进展
Research advances in insulin-like growth factor 1 receptor and its pathway in diagnosis and treatment of primary liver cancer
文章发布日期:2017年03月08日  来源:  作者:赵曌,亓文骞,赵平  点击次数:1599次  下载次数:364次

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【摘要】:胰岛素样生长因子1受体(IGF-1R)的生物学功能主要表现为形成并维持细胞的转化表型,参与细胞增殖、分化,抑制细胞的凋亡。除此之外,IGF-1R对细胞周期具有调节作用,与表皮生长因子、血小板衍生生长因子共同作用,介导细胞周期从G1期进入S期。过度表达的IGF-1R己经成为原发性肝癌影像诊断及定位治疗的热点靶蛋白之一。抑制IGF-1R的表达或功能可有效控制肿瘤细胞生长和转移,并增强其对化疗、放疗的敏感性。综述了IGF-1R及其通路在原发性肝癌诊断及治疗中的作用及意义。
【Abstract】:The main biological functions of insulin-like growth factor 1 receptor (IGF-1R) include formation and maintenance of transformed cell phenotype, involvement in cell proliferation and differentiation, and inhibition of cell apoptosis. In addition, IGF-1R regulates cell cycle and works with epidermal growth factor and platelet-derived growth factor to mediate cells to enter S phase from G1 phase. Overexpressed IGF-1R has become one of the target proteins for diagnostic imaging and localization therapy for primary liver cancer. Inhibition of the expression or function of IGF-1R can effectively control the growth and metastasis of tumor cells and enhance their sensitivity to chemotherapy and radiotherapy. This article reviews the role and significance of IGF-1R and its pathway in the diagnosis and treatment of primary liver cancer.
【关键字】:肝肿瘤; 受体, IGF1型; 诊断; 治疗; 综述
【Key words】:liver neoplasms; receptor, IGF type 1; diagnosis; therapy; review
【引证本文】:赵曌, 亓文骞, 赵平. 胰岛素样生长因子1受体及其通路在原发性肝癌诊治中的研究进展[J]. 临床肝胆病杂志, 2017, 33(4): 763-768.

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