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Yes相关蛋白在肝细胞癌与胆管细胞癌中的表达特征及其与预后的关系
Expression features and prognostic significance of Yes-associated protein in hepatocellular carcinoma and cholangiocellular carcinoma
文章发布日期:2017年06月07日  来源:  作者:王春, 邬昊, 刘彦,等  点击次数:1357次  下载次数:255次

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【摘要】:目的探讨Yes相关蛋白(YAP蛋白)在肝细胞癌与胆管细胞癌中的表达与患者临床预后的相关性。方法收集2004年7月-2009年7月重庆医科大学附属第二医院收治的190例肝癌患者标本,其中肝细胞癌110例,胆管细胞癌80例。分析不同组别YAP蛋白表达水平的差异,比较不同组别患者的预后情况。YAP蛋白的表达与肝细胞癌、胆管细胞癌患者临床病理特征之间关系比较采用χ2检验。采用Kaplan-Meier与log-rank检验分析患者的无瘤生存率与总生存率。采用Cox回归分析YAP蛋白的表达对肝细胞癌与胆管细胞癌患者预后的影响。结果YAP蛋白在胆管细胞癌中的高表达率为68.7%,比肝细胞癌中的高表达率(56.3%)高。在肝细胞癌与胆管细胞癌中,YAP蛋白的高表达在不同肿瘤大小(P值分别为<0.001、0.024)、不同AFP水平(P值分别为0.009、0.034)、是否有肝硬化(P值分别为0.032、0.006)、是否存在血管侵犯(P值分别为0.011、0.028)和肝内转移(P值分别为0.049、0030)的患者间,差异均有统计学意义。在肝细胞癌与胆管细胞癌患者中,YAP蛋白高表达者无瘤生存率和总生存率显著低于YAP蛋白低表达者(P值均<005)。多因素结果显示,YAP蛋白高表达均为影响肝细胞癌和胆管细胞癌患者无瘤生存率和总生存率的危险因素(P值均<005)。结论肝细胞癌与胆管细胞癌中可发现较高水平的YAP蛋白表达,且YAP蛋白的高表达与患者的低生存率有关。
【Abstract】:ObjectiveTo investigate the expression of Yes-associated protein (YAP) in hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CC) and its association with clinical prognosis. MethodsSamples were collected from 190 patients who were treated in The Second Hospital Affiliated to Chongqing Medical University from July 2004 to July 2009, among whom 110 had HCC and 80 had CC. The difference in YAP expression and its association were analyzed in both groups, and patients′ prognosis was compared between the two groups. The chi-square test was used to investigate the association between YAP expression and clinicopathological features of HCC and CC, and the Kaplan-Meier method and the log-rank test were used to assess tumor-free survival rate and overall survival rate. A univariate Cox regression analysis was used to evaluate the influence of YAP expression on the prognosis of patients with HCC and CC. ResultsThe CC group had higher expression of YAP than the HCC group (68.7% vs 56.3%, P=0.036). High YAP expression in HCC and CC was significantly associated with tumor size (P<0.001 and P=0.024), alpha fetoprotein (P=0.009 and 0034), liver cirrhosis (P=0032 and 0.006), vascular invasion (P=0.011 and 0.028), and intrahepatic metastasis (P=0.049 and 0030). In both groups, the patients with high YAP expression had significantly lower tumor-free survival rate and overall survival rate than those with low YAP expression(all P<005). Multivariate analysis showed that high YAP expression is an adverse prognostic factor for tumor-free survival and overall survival in both groups (all P<005). ConclusionHigh YAP expression is frequently found in patients with HCC and CC, and high YAP expression is associated with low survival rate.
【关键字】:肝肿瘤,实验性;Yes相关蛋白;预后
【Key words】:liver neoplasms, experimenal;Yes-associated protein;prognosis
【引证本文】:王春,邬昊,刘彦,等. Yes相关蛋白在肝细胞癌与胆管细胞癌中的表达特征及其与预后的关系[J]. 临床肝胆病杂志, 2017, 33(7): 1310-1315.

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