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let-7在肝细胞癌诊疗中的机制及意义
Mechanism and significance of let-7 in diagnosis and treatment of hepatocellular carcinoma
文章发布日期:2017年06月07日  来源:  作者:霍婷婷,王东旭,张明智,等  点击次数:895次  下载次数:158次

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【摘要】:microRNA(miRNA)在转录后水平发挥重要的基因调控作用。近年来,随着miRNA在肿瘤发生、发展中的研究成为热点,恶性肿瘤的基因靶向治疗也取得了初步成就。miRNA let-7是最早发现的miRNA之一,可调控细胞周期、血管生成等,尤其是参与调节多种肿瘤细胞的增殖、分化和凋亡;let-7家族多数成员有抑癌基因的作用,在多种肿瘤组织中呈低表达而在恶性肿瘤患者血清中呈高表达;let-7与肝细胞癌(HCC)的侵袭性和耐药性密切相关,表明let-7有望成为肝癌早期诊断标志物,并为HCC治疗提供新的靶点。
【Abstract】:MicroRNA (miRNA) play important roles in post-transcriptional gene regulation. In recent years, miRNA has become a hot topic in the research on the development and progression of tumors, and gene targeting therapy for malignant tumors has achieved preliminary progress. As one of the first discovered miRNA, let-7 can regulate the cell cycle and angiogenesis and is involved in the proliferation, differentiation, and apoptosis of various tumor cells. Most members of the let-7 family can act as tumor suppressor gene and have low expression in various tumor tissues and high expression in the serum of patients with malignant tumors. Let-7 is closely associated with the invasion and drug resistance of hepatocellular carcinoma (HCC). The studies above show that let-7 might become a new marker for the early diagnosis of HCC and provide new targets for the treatment of HCC.
【关键字】:微RNA; 癌, 肝细胞; 综述
【Key words】:microRNAs; let-7; carcinoma, hepatocellular; review
【引证本文】:霍婷婷, 王东旭, 张明智, 等. let-7在肝细胞癌诊疗中的机制及意义[J]. 临床肝胆病杂志, 2017, 33(7): 1377-1380.

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