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非酒精性脂肪性肝病发病机制新认识
A new understanding of the pathogenesis of nonalcoholic fatty liver disease
文章发布日期:2017年07月07日  来源:  作者:辛晟梁,徐可树  点击次数:1181次  下载次数:286次

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【摘要】:近年来我国非酒精性脂肪性肝病(NAFLD)发病率越来越高,达到11%~15%。目前认为“多次打击”学说是NAFLD的主要发病机制,但确切机制尚未明确。从肝脏高表达蛋白质癌胚抗原相关细胞黏附分子1、维生素D受体轴、精神心理因素等3个较为新颖的角度阐述了其与NAFLD发生发展的关系,以期为今后研究NAFLD发病机制提供新的方向。
【Abstract】:The incidence rate of nonalcoholic fatty liver disease (NAFLD) has been increasing in China in recent years and has reached 11%-15%. At present, the "multiple-hit" hypothesis is considered the main pathogenesis of NAFLD, yet the specific pathogenesis remains unknown. This article elaborates on the roles of carcinoembryonic antigen-related cell adhesion molecule 1 highly expressed in the liver, vitamin D/vitamin D receptor axis, and psychological factors in the development and progression of NAFLD, in order to provide new directions for the research on the pathogenesis of NAFLD in future.
【关键字】:脂肪肝;细胞黏附分子;维生素D;精神障碍;综述
【Key words】:fatty liver; cell adhesion molecules; vitamin D; mental disorders; review
【引证本文】:辛晟梁, 徐可树. 非酒精性脂肪性肝病发病机制新认识[J]. 临床肝胆病杂志, 2017, 33(8): 1581-1583.

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