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槐耳颗粒联合经肝动脉化疗栓塞术治疗肝细胞癌的研究进展
Research advances in Huai′er granules combined with transarterial chemoembolization in treatment of hepatocellular carcinoma
文章发布日期:2017年09月07日  来源:  作者:董德硕, 刘兆玉  点击次数:1262次  下载次数:222次

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【摘要】:肝细胞癌起病隐匿,发现时多数已失去手术机会,主要采用经肝动脉化疗栓塞术(TACE)姑息治疗。然而反复TACE会导致缺氧诱导因子1(HIF-1)及血管内皮生长因子(VEGF)高表达、肝损伤、免疫功能降低,远期疗效并不理想,槐耳颗粒的引入有望改变这一现状。槐耳颗粒通过阻滞细胞周期、诱导细胞凋亡、抑制细胞增殖与侵袭、阻断乙型肝炎-肝细胞癌途径发挥抗肿瘤作用,同时,槐耳颗粒作为肝细胞癌辅助用药在多方面弥补TACE的不足之处,有效抑制HIF-1α及VEGF高表达、改善肝损伤、提高免疫力、增强化疗药效果并逆转耐药。槐耳颗粒与TACE联合治疗肝细胞癌优势显著,两者协同作用提高了抗肿瘤疗效及近、远期生存率。
【Abstract】:Hepatocellular carcinoma (HCC) has an insidious onset and when a confirmed diagnosis is made, most patients lose the chance for surgery and are given transarterial chemoembolization (TACE) as palliative treatment. However, repeated TACE may lead to overexpression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF), liver injury, and reduced immune function and has poor long-term efficacy. The introduction of Huai′er granules may help to change the current status. Studies in China and foreign countries have shown that Huai′er granules exert a remarkable anti-tumor effect by blocking cell cycle, inducing cell apoptosis, inhibiting cell proliferation and invasion, and blocking the hepatitis B-hepatocellular carcinoma pathway. Meanwhile, as an adjuvant drug for HCC, Huai′er granules cover the shortcomings of TACE from multiple aspects and can effectively inhibit the overexpression of HIF-1α and VEGF, improve liver injury and immunity, enhance the effect of chemotherapy drugs, and reverse drug resistance. Many clinical studies have confirmed the remarkable advantages of Huai′er granules combined with TACE, and their synergistic effect helps to enhance anti-tumor effect and improve short- and long-term survival rates.
【关键字】:癌, 肝细胞; 槐耳颗粒; 化学栓塞, 治疗性; 综述
【Key words】:carcinoma, hepatocellular; Huaier granule; chemoembolization, therapeutic; review
【引证本文】:董德硕, 刘兆玉. 槐耳颗粒联合经肝动脉化疗栓塞术治疗肝细胞癌的研究进展[J]. 临床肝胆病杂志, 2017, 33(10): 2021-2024.

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