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2型糖尿病伴高甘油三酯血症患者发生急性胰腺炎的影响因素分析
Influencing factors for acute pancreatitis in patients with type 2 diabetes complicated by hypertriglyceridemia
文章发布日期:2017年11月07日  来源:  作者:白云磊,党润芳  点击次数:1116次  下载次数:202次

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【摘要】:目的探讨2型糖尿病患者并发高甘油三酯血症与急性胰腺炎发生的关系,以指导糖尿病患者急性胰腺炎的预防和治疗。方法选取2013年1月-2016年12月榆林市第一医院收治的2型糖尿病并发急性胰腺炎患者46例为试验组,另选取本院同期收治的单纯2型糖尿病患者52例为对照组。记录患者的年龄、性别、糖尿病病程、身高、体质量、腹围、吸烟、饮酒、胆结石、高血压、血糖、血脂情况[TC、TG、HDL-C、LDL-C]。检测患者糖尿病相关并发症的发生情况。计数资料2组间比较采用χ2检验,计量资料2组间比较采用t检验;采用logistic回归进行多因素分析。结果2组患者在年龄、性别构成、身高、体质量、腹围、吸烟饮酒习惯、高血压、胆结石、糖尿病病程等方面的差异无统计学意义(P值均>0.05);试验组患者的TC、TG、LDL-C水平均显著高于对照组,差异均有统计学意义(t值分别为5.122、4.127、3.524,P值分别为<0.01、<0.01、0.012),对照组患者的HDL-C水平显著高于试验组,差异统计学意义(t=2.231,P=0.037);试验组患者的糖尿病微血管病变(糖尿病视网膜病变、糖尿病慢性肾病)发病率显著高于对照组(χ2=92.126,P<0.01);多因素分析结果显示,高TG水平的2型糖尿病患者发生急性胰腺炎的风险较TG水平正常的患者增加了47.6%(比值比=1.476,P=0.031),高LDL-C的2型糖尿病患者发生急性胰腺炎的风险较LDL-C水平正常的患者增加了48.7%(比值比=1.487,P=0.045)。结论应加强对2型糖尿病患者的血脂检测,针对伴高甘油三酯血症的2型糖尿病患者应积极控制血糖、血脂水平,以降低急性胰腺炎的发生率。
【Abstract】:ObjectiveTo investigate the association between hypertriglyceridemia and acute pancreatitis in patients with type 2 diabetes, in order to guide the prevention and treatment of acute pancreatitis in patients with diabetes. MethodsA total of 46 patients with type 2 diabetes complicated by acute pancreatitis who were admitted to The First Hospital of Yulin from January 2013 to December 2016 were enrolled as study group, and 52 patients with type 2 diabetes alone who were admitted to our hospital within the same period of time were enrolled as control group. Related data were recorded, including age, sex, course of diabetes, body height and weight, abdominal circumference, smoking, drinking, gallstones, hypertension, blood glucose, and blood lipids [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)]. The incidence rates of complications associated with diabetes were analyzed. The chi-square test was used for comparison of categorical data (general status, blood lipids, and diabetic complications) between two groups; and the t-test was used for comparison of such data between two groups. A logistic regression analysis was used for multivariate analysis. ResultsThere were no significant differences between the two groups in age, sex composition, body height and weight, abdominal circumference, smoking and drinking habits, hypertension, gallstones, and course of diabetes (all P>0.05). The study group had significantly higher levels of TC, TG, and LDL-C than the control group (t=5.122, 4.127, and 3.524, P<0.01, <0.01, and =0.012), while the control group had a significantly higher level of HDL-C than the study group (t=2.231, P=0.037). The study group had a significantly higher incidence rate of diabetic microangiopathy (diabetic retinopathy and chronic diabetic nephropathy) than the control group (χ2=92.126, P<0.01). The multivariate analysis showed that compared with those with a normal TG level, the type 2 diabetic patients with a high TG level had a risk of acute pancreatitis increased by 47.6% (odds ratio [OR]=1.476, P=0.031), and the type 2 diabetic patients with a high LDL-C level had a risk of acute pancreatitis increased by 48.7% (OR=1.487, P=0.045). ConclusionBlood lipids should be measured for patients with type 2 diabetes, and blood glucose and blood lipid levels should be actively controlled for patients with type 2 diabetes complicated by hypertriglyceridemia, in order to reduce the incidence rate of acute pancreatitis.
【关键字】:糖尿病,2型;高甘油三酯血症;胰腺炎;危险因素
【Key words】:diabetes mellitus,type 2;hypertriglyceridemia;pancreatitis;risk factors
【引证本文】:BAI YL, DANG RF. Influencing factors for acute pancreatitis in patients with type 2 diabetes complicated by hypertriglyceridemia[J]. J Clin Hepatol, 2017, 33(12): 2350-2354. (in Chinese)
白云磊, 党润芳. 2型糖尿病并发高甘油三酯血症患者发生急性胰腺炎的影响因素分析[J]. 临床肝胆病杂志, 2017, 33(12): 2350-2354.

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