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聚乙二醇干扰素α-2a治疗非活动性HBsAg携带者HBsAg清除与血清粒-巨噬细胞集落刺激因子水平的关系
Association between HBsAg clearance and serum level of granulocyte-macrophage colony stimulating factor in inactive HBsAg carriers receiving pegylated interferon alpha-2a
文章发布日期:2018年04月04日  来源:  作者:曹振环,鲁俊锋,武亚丽,等  点击次数:410次  下载次数:50次

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【摘要】:目的探讨聚乙二醇干扰素(PEG-IFN)α-2a治疗非活动性HBsAg携带者(IHC)发生HBsAg清除与血清粒-巨噬细胞集落刺激因子(GM-CSF)水平的关系。方法收集2013年1月-2016年1月就诊于首都医科大学附属北京佑安医院门诊的IHC患者20例,经PEG-IFNα-2a治疗24周后13例获得HBsAg清除(R组),7例未获得HBsAg清除(NR组)。用Luminex技术检测患者基线、治疗12周和治疗24周血清GM-CSF水平。同时检测11例健康人(HC组)血清GM-CSF水平。计量资料2组间比较采用t检验,多组间比较采用方差分析,进一步两两比较采用Bonferroni检验。计数资料组间比较采用χ2检验。结果R组、NR组及HC组基线血清GM-CSF水平分别为(42.63±11.24)pg/ml、(46.77±10.52)pg/ml(11.97±3.85)pg/ml,3组之间比较差异具有统计学意义(F=4.482,P=0.02),R组与NR组GM-CSF水平均明显高于HC组(P值均<005)。PEG-IFNα-2a治疗后12周和24周,R组血清GM-CSF水平均明显高于NR组[(83.31±14.20)pg/ml vs (25.90±7.06)pg/ml,t=22.422,P<0001;(3234±806)pg/ml vs (943±245)pg/ml,t=17782,P=0001]。R组患者基线抗病毒治疗12周、24周时,血清GM-CSF水平呈现先升高后下降趋势,3个时间点比较,差异有统计学意义(F=7.655,P=0.002)。NR组患者基线抗病毒治疗12周、24周时,血清GM-CSF水平呈明显下降趋势,3个时间点比较,差异有统计学意义(F=5.264,P=0016)。结论PEG-IFNα-2a治疗IHC过程中血清GM-CSF水平升高可能预示着HBsAg清除。
【Abstract】:ObjectiveTo investigate the association between HBsAg clearance and serum level of granulocyte-macrophage colony stimulating factor (GM-CSF) in inactive HBsAg carriers receiving pegylated interferon (PEG-IFN) alpha-2a.MethodsA total of 20 inactive HBsAg carriers who visited Beijing YouAn Hospital, Capital Medical University, from January 2013 to January 2016 were enrolled, and after 24 weeks of PEG-IFN alpha-2a treatment, 13 achieved HBsAg clearance (R group) and 7 did not achieve HBsAg clearance (NR group). The Luminex technique was used to measure the serum level of GM-CSF at baseline and at weeks 12 and 24 of treatment. The serum level of GM-CSF was also measured for 11 healthy controls (HC group). The t-test or an analysis of variance was used for comparison of continuous data between groups, and the Bonferroni test was used for further comparison between two groups. The chi-square test was used for comparison of categorical data between groups. ResultsThe R and NR groups had a significantly higher serum GM-CSF level than the HC group (42.63±11.24 pg/ml and 46.77±10.52 pg/ml vs 11.97±3.85 pg/ml), and there was a significant difference between the three groups (F=4.482, P=0.02). At weeks 12 and 24 of PEG-IFNα-2a treatment, the R group had a significantly higher serum GM-CSF level than the NR group (t=22.422 and 17.782, both P<0.05). In the R group, the serum GM-CSF level was 42.63±1125 pg/ml at baseline, significantly increased to 83.31±14.20 pg/ml at week 12 of treatment, and then significantly decreased to 32.34±8.06 pg/ml at week 24 of treatment (F=7.655, P=0.002). In the NR group, the serum GM-CSF level was 46.77±10.52 pg/ml at baseline and significantly decreased to 2590±7.06 pg/ml at week 12 of treatment and 9.43±2.45 pg/ml at week 24 of treatment (F=5.264, P=0.016). ConclusionIn inactive HBsAg carriers receiving PEG-IFN alpha-2a treatment, the increase in serum GM-CSF level may indicate HBsAg clearance.
【关键字】:肝炎病毒, 乙型; 肝炎表面抗原, 乙型; 聚乙烯二醇类; 干扰素类; 粒细胞巨噬细胞集落刺激因子
【Key words】:hepatitis B virus; hepatitis b surface antigens; polyethylene glycols; interferons; granulocyte-macrophage colony-stimulating factor
【引证本文】:CAO ZH, LU JF, WU YL, et al. Association between HBsAg clearance and serum level of granulocyte-macrophage colony stimulating factor in inactive HBsAg carriers receiving pegylated interferon alpha-2a[J]. J Clin Hepatol, 2018, 34(5): 1001-1004. (in Chinese) 曹振环, 鲁俊锋, 武亚丽, 等. 聚乙二醇干扰素α-2a治疗非活动性HBsAg携带者HBsAg清除与血清粒-巨噬细胞集落刺激因子水平的关系[J]. 临床肝胆病杂志, 2018, 34(5): 1001-1004.

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