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【摘要】：目前，非酒精性脂肪性肝病（NAFLD）已经成为全球慢性肝病的主要病因，是隐源性肝硬化的常见致病因素。临床上，NAFLD患者多见于肥胖群体，但非肥胖人群中NAFLD亦不罕见，尤其是亚洲人群。非肥胖型NAFLD与肥胖型NAFLD代谢谱相当，但最近多项研究显示与肥胖型NAFLD相比，非肥胖型肝纤维化、肝硬化有其独特的特点。回顾了近年来非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素，以期更好地了解该病的预防、诊断和治疗。
【Abstract】：At present, non-alcoholic fatty liver disease (NAFLD) has become the major cause of chronic liver disease in the world and is considered a common pathogenic factor of cryptogenic cirrhosis. In clinical practice, NAFLD is commonly seen in obese patients; however, it is not rare among non-obese individuals, especially in the Asian population. Non-obese NAFLD patients have similar metabolic profiles to obese NAFLD patients, but many studies have revealed that compared with obese NAFLD, non-obese liver fibrosis and liver cirrhosis have unique features. This article reviews the research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis in recent years, in order to gain a better understanding of the prevention, diagnosis, and treatment of this disease.
【关键字】：非酒精性脂肪性肝病; 肝硬化; 综述
【Key words】：non-alcoholic fatty liver; liver cirrhosis; review
【引证本文】：CHEN YZ, CHEN CL, HONG Y, et al. Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis［J］. J Clin Hepatol, 2018, 34(10): 2227-2231. (in Chinese)
陈艳珍， 陈成良， 洪宇， 等. 非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素［J］. 临床肝胆病杂志, 2018, 34(10): 2227-2231.