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The pathogenicity and pathologic character of HGV for chronic Hepatitis/Cirrhosis
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摘要: 探讨HGV在慢性肝炎肝硬化当中感染率、临床及病理特征 ,应用ELISA法检测血清抗 -HGV ,用HGVNS5抗原制备MCAb ,检测 5 4例慢性肝炎肝硬化患者肝组织中HGV抗原 ,同时应用SP法分别对肝组织进行HBsAg、HBcAg、HCVNS3 Ag肝脏免疫组化检测。结果提示 5 4例肝病患者肝组织检出 2 7 78%HGV抗原阳性。其中 2 4例慢性肝炎轻度中 5例 ;16例慢性肝炎中度中 5例 ;15例肝硬化中 5例。HGV重叠HBV或HCV二重感染及HBV、HCV三重感染为主 ,占 80 % ,单独HGV感染者占 2 0 %。HGV在肝脏内主要定位于胞浆型 ,部分同时核型表达或单独核型表达 ,有 1例单纯枯否氏细胞内HGAg阳性表达。HGV单独感染者临床隐匿性发病 ,预后好 ,HGV重叠HBV、HCV感染在慢性肝炎病期进展具有一定意义Abstract: WT5”BZ]To study the infection rate, the clinical and pathologic character of HG (Hepatitis G) , including chronic hepatitis and cirrhosis, We detected anti-HGV in serum by EIA and prepared McAb by HGV NS 5 to detect HGV in the hepatic tissues of 54 patients with chronic hepatitis and cirrhosis, also performed with SP immunohistochemical detection of HBsAg, HBcAg and HCVSN 3Ag in hepatic tissue of the patients HGV was found in 15 cases (27 8%) each one-third of which were respectively from 24 ligh mild degree, 16 medium degree and 14 cirrhosis patients (5/24, 5/16, 5/14) Mainly, Coinfection of HGV with HBV/HCV anounts to 80% but patients with HGV alone account for 20% HGV was found mainly in cytoplasm, some in cytonucleus sinultaneously or only in cytonucleus One case showed that HGAg was positive simply in Kuffer’s cell The patient with HGV alone gets sick in clinical concealment with prognosis favorable The coinfection of HGV with HBV/HCV may have significance for chronic hepatitis development [WT5”HZ]
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〔1〕SimmonsJN , Pilot-MatiastTJ, LearyTP , etal Identificationoftwofla vivirus-likegenomesintheGBhepatitisagent ProceedingsofNationalA cademyofSciencesUSA , 1995 , 92∶3 4 0 1 []〔2〕LinnenJI , WagesJ, Zhang -keckZY , etal MolecularcloninganddiseaseassociationofhepatitisGvirus:atransfusiontransmissibleagent Science , 1996, 2 71∶5 0 5 〔3〕SchlaudeGG , DawsonGJ , SimmonsJN , etal MolecularandseiologicinthetransmissionoftheGBhepatitsagent JourndlofMedicalVirology , 1995 , 46∶81 []〔4〕周育森 , 王海涛 , 何玉先 , 等 中国人庚型肝炎病毒全基因结构特点及HGV感染的地理分布 微生物学通报 , 1997, 2 4∶2 7-3 1 -
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