血清微量元素变化对肝硬化骨代谢异常的影响及病理学改变

陈自平; 刘倩; 王文奇; 王义国; 闫明先

血清微量元素变化对肝硬化骨代谢异常的影响及病理学改变

详细信息

中图分类号: R575.2
计量
- 文章访问数: 2122
- HTML全文浏览量: 11
- PDF下载量: 725
- 被引次数: 0
出版历程
- 出版日期: 2003-06-20

Variation of serum trace elements on bone abnormal metabolism and pathological alteration in patients with cirrhosis of liver

摘要

摘要: 为探讨血清微量元素变化对肝硬化骨代谢异常的影响及病理学改变。采用原子吸收分光光度计等方法分别测定 32例肝硬化患者铜 (Cu)、锌 (Zn)、硒 (Se)、镉 (Cd)、铝 (Al)水平 ,并与 31例健康者对照。其中 17例患者及 12例健康者行骨组织学观察。结果表明 ,肝硬化组血清Zn、Se水平较对照组明显下降 (P <0 0 0 1,P <0 0 1) ,而血清Cd、Al水平明显升高 (P <0 0 0 1,P <0 0 0 1)。组织学发现 14例骨质疏松 (OP) ,OP发生率为 82 35 %。OP患者重度组血清Zn、Se水平较轻度组明显下降 (P <0 0 5 ,P <0 0 5 ) ,而血清Cd、Al水平显著升高 (P <0 0 1,P <0 0 1)。提示肝硬化患者血清Zn、Se、Cd、Al存在明显异常 ,在肝性骨病 (HBD)的形成过程中均起着不可忽视的作用。适当补充Zn、Se ,而减少Cd、Al摄入 ,对HBD的防治将产生有益作用
- 肝硬化 /
- 微量元素 /
- 骨组织学 /
- 肝性骨病
Abstract: To discuss the influence of trace elements on bone abnormal metabolism and pathological alteration in patients with cirrhosis of liver, levels of serum Cu?Zn?Se?Cd?Al were detected by atom resorption spectrophotometer in 32 cirrhosis and 31 age-matched healthy controls. Bone histology was observed among 17 cirrhosis and 12 controls. The results showed that serum Zn?Se in cirrhosis decreased more than that of controls (P<0.001, P<0.01) , but serum Cd?Al in cirrhosis increased much higher than controls respectively (P<0.001, P<0.001) . 14 osteoporosis (OP) were observed in 17 cirrhosis. The incidence of OP was 82.35%. Serum Zn?Se reduced (P<0.05, P<0.05) and Cd?Al raised (P<0.01, P<0.01) in low-grade vs. high-grade. It was suggested that serum Zn?Se?Cd?Al existenced obvious abnormality in cirrhosis. These trace elements had no neglect effect on the formation of HBD. Proper complementation of Zn?Se and diminution intake of Cd?Al may be play beneficial role for prevention and treatment of HBD.
- Cirrhosis of liver /
- Trace element /
- Bone histology /
- Hepatic bone disease

HTML全文

参考文献(7)

[1]DiamondH , StielD , LunzerM , etal.Hepaticosteodystrophy, staticanddynamicbonehistomorphometryandserumbonegla-proteinin80patientswithchronicliverdisease[J].Gastroenterology, 1989, 96∶212.

[2]陈自平, 刘倩, 王文奇, 等.乙肝后肝硬化患者血清调钙激素变化对骨代谢的影响[J].中华肝脏病杂志, 2001, 9 (6) ∶374.

[3]陈自平, 刘倩, 王文奇, 等.乙肝后肝硬化患者血清IL -1β、TNF -α变化对骨代谢影响的临床研究[J].临床肝胆病杂志, 2000, 16 (4) ∶216～217.

[4]余增丽.锌与骨质疏松[J].国外医学·老年医学分册, 2000, 21 (1) ∶7～8.

[5]卢胜春, 徐新春, 王光荣.肝硬化患者血清微量元素研究[J].临床消化病杂志, 1997, 9 (3) ∶109～111.

[6]郑高利, 郑筱祥, 张信岳, 等.骨质疏松大鼠胫骨微量元素的变化及相关性研究[J].浙江大学学报·医学版, 2002, 31 (3) ∶185～188.

[7]陈自平, 刘倩, 王文奇, 等.肝硬化患者血清1, 25 (OH) 2D3变化对骨代谢的影响[J].临床消化病杂志, 1999, 11 (4) ∶156～157

施引文献

资源附件(0)

访问统计