乙型肝炎3个候选基因单核苷酸多态性的初步调查

邓春青; 王宇明; 邓国宏

乙型肝炎3个候选基因单核苷酸多态性的初步调查

基金项目:

国家自然科学基金资助(30200234,30230320)；

详细信息

中图分类号: R450
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出版历程
- 出版日期: 2006-01-20

Prelininary study on candidate genes SNP about hepatitis B.

Research funding:

摘要

摘要: 了解人群中乙型肝炎候选基因FGL2、eNOS、HMGB1的SNP,为大规模筛查奠定基础。采用PCR及限制性内切酶技术判定基因型并进行Hardy-Weinberg遗传平衡定律检验。除FGL2 111T/C位点等位基因频率为0放弃继续检测外,其他位点频率大于5%而且符合Hardy-Weinberg平衡,说明该人群具有良好的代表性,可在收集的大量患者中检测以进一步明确与乙型肝炎的关系。
- FGL2 /
- eNOS /
- HMGB1 /
- 单核苷酸多态性 /
- HBV
Abstract: To investigate the polymorphisms of hepatitis B candidate genes FGL2, eNOS and HMGB1 of patients from infections department in Xinan Hospital.The polymorphisms were analyzed with PCR and restriction enzymes, and were detected with Hardy-Weinberg equilibrium.It shows that the observed genepolymorphism, except in FGL2 111/C position, are in Hardy-Weinberg genetic equilibrium.The study will be processed in a larger scale (except in FGL2 111/C position) to characterize the relationship between hepatitis B and these genotypes.
- FGL2 /
- eNOS /
- HMGB1 /
- single nucleotide polymorphism /
- HBV

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参考文献(6)

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