丙型肝炎病毒感染与治疗药物

戚中田

丙型肝炎病毒感染与治疗药物

戚中田

第二军医大学微生物教研室

基金项目:

国家传染病重大专项课题(2008ZX10002-013)；国家新药创制重大专项课题(2008ZXJ09009-002)；上海市重点学科建设项目(B901)；

详细信息

中图分类号: R512.63
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出版历程
- 出版日期: 2011-01-20

Hepatitis C virus infection and its therapeutic drugs

Qi ZhongTian

Research funding:

摘要

摘要:
丙型肝炎病毒（HCV）通过在宿主细胞内持续复制,导致慢性感染。目前用于治疗慢性丙型肝炎（CHC）的药物主要是聚乙二醇干扰素（PEG-IFN）和利巴韦林的联合用药。本文将就HCV的细胞入侵、复制、逃避宿主的固有和获得性免疫,以及抗HCV临床试验药物的最新进展做一综述。
- 肝炎,丙型 /
- 肝炎病毒属
Abstract:
Hepatitis C virus (HCV) can lead to chronic hepatitis C (CHC) in ways that favor viral replication and persistent infection.The current standard treatment for hepatitis C virus infection is the combination of pegylated IFN with ribavirin (PEG-IFN/RBV) .In the recent years there has been significant advances in the understanding of viral replication and the development of anti-virus agents.This review summarizes the current knowledge of HCV cell entry, replication, escaping host innate and adaptive immune responses and current clinical trails of anti-HCV drugs.
- hepatitis C /
- hepacivirus

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参考文献(25)

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