胰管高压导致高脂血症性急性胰腺炎的发病机制

冯佳晨; 张平

doi:10.12449/JCH240134

胰管高压导致高脂血症性急性胰腺炎的发病机制

DOI: 10.12449/JCH240134

冯佳晨,
张平^, ,

吉林大学第一医院普通外科中心-肝胆胰外一科，长春 130021

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张平负责课题设计；张平、冯佳晨进行查阅文献并起草论文，论文撰写及修改、校阅论文。

详细信息

通信作者:
张平， z_ping@jlu.edu.cn （ORCID： 0000-0003-4944-2937）

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出版历程
- 收稿日期: 2023-09-27
- 录用日期: 2023-11-24
- 出版日期: 2024-01-23

The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

Jiachen FENG,
Ping ZHANG^{,
,}

First Department of Hepatopancreatobiliary Surgery，Center of General Surgery，The First Hospital of Jilin University，Changchun 130021，China

More Information

Corresponding author: ZHANG Ping， z_ping@jlu.edu.cn （ORCID： 0000-0003-4944-2937）

摘要

摘要: 高脂血症性急性胰腺炎与其他病因的急性胰腺炎相比，重症率更高，预后更难预测，发病机制复杂且不清晰。目前已知的发病机制可能与血清游离脂肪酸升高有关，但降低血脂的治疗方案并未降低本病的发病率。近期，胰管高压是急性胰腺炎重要的发病机制被进一步证实，而最新研究进展表明高脂血症可通过引起胰管增生、形成胆胰管汇合部蛋白栓、损伤胰管的分泌功能来导致胰管堵塞，胰管堵塞又可引起胰管高压。本文综述了高脂血症在导致胰管堵塞方面的最新研究和进展，并强调胰管高压是高脂血症性急性胰腺炎重要的发病机制之一，这将为研究高脂血症性急性胰腺炎的发病机制提供新的思路。
- 胰腺炎 /
- 胰管高压 /
- 高脂血症
Abstract: Compared with acute pancreatitis caused by other factors， hyperlipidemic acute pancreatitis often has a higher rate of severe conditions， greater difficulties in predicting prognosis， and a more complex and unclear pathogenesis. At present， the pathogenesis of hyperlipidemic acute pancreatitis may be associated with the elevation of serum free fatty acids， but the lipid-lowering treatment regimens do not reduce the incidence rate of this disease. Recent studies have further confirmed that pancreatic duct hypertension is an important pathogenesis of acute pancreatitis. The latest research advances have shown that hyperlipidemia can lead to pancreatic duct obstruction by causing pancreatic duct hyperplasia， forming protein embolism at the biliary-pancreatic junction， and damaging the secretory function of the pancreatic duct， while pancreatic duct obstruction can in turn cause pancreatic duct obstruction. This article reviews the latest research advances in hyperlipidemia in causing pancreatic duct obstruction and emphasizes that pancreatic duct hypertension is one of the important pathogeneses of hyperlipidemic acute pancreatitis， which will provide new ideas for exploring the pathogenesis of hyperlipidemic acute pancreatitis.
- Pancreatitis /
- Pancreatic duct hypertension /
- Hyperlipidemias

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图 1 正常胆胰管合流-V型

Figure 1. Normal bile pancreatic duct confluence -V type

下载: 全尺寸图片幻灯片

图 2 正常胆胰管合流-小Y型

Figure 2. Normal biliary pancreatic duct confluence - small Y pattern

下载: 全尺寸图片幻灯片

图 3 异常胆胰管合流B-P型

Figure 3. Abnormal biliary pancreatic duct confluence B-P type

下载: 全尺寸图片幻灯片

图 4 异常胆胰管合流P-B型

Figure 4. Abnormal biliopancreatic duct confluence P-B type

下载: 全尺寸图片幻灯片

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