骨形态发生蛋白7/Smads信号通路及其在肝纤维化进程中的作用

侯斐; 刘瑞霞; 阴赪宏

doi:10.3969/j.issn.1001-5256.2016.05.046

骨形态发生蛋白7/Smads信号通路及其在肝纤维化进程中的作用

DOI: 10.3969/j.issn.1001-5256.2016.05.046

1. 首都医科大学附属北京友谊医院感染内科
2. 首都医科大学附属北京妇产医院内科

基金项目:

国家自然科学基金(81300334)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2016-05-20

Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis

Research funding:

摘要

摘要: 肝纤维化是由于各种病因导致肝损伤后,机体对损伤进行修复的过程。近年来研究发现骨形态发生蛋白（BMP）7及其下游的Smads蛋白可以通过不同的途径拮抗转化生长因子（TGF）β1的致肝纤维化作用,包括诱导细胞外基质降解,抑制细胞凋亡,减少多种促炎症因子的表达,促进肝细胞再生等,探讨了BMP-7/Smads信号通路在肝纤维化过程中的作用。
- 肝硬化 /
- 骨形态发生蛋白质类 /
- Smad蛋白质类 /
- 转化生长因子β1 /
- 综述
Abstract: Hepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein- 7( BMP- 7) and the downstream Smads can antagonize the effect of transforming growth factor- β1,which induces hepatic fibrosis,through various pathways,including inducing the degradation of extracellular matrix,inhibiting cell apoptosis,reducing the expression of various proinflammatory factors,and promoting the regeneration of hepatocytes. This article investigates the role of BMP- 7 / Smads signaling pathway in hepatic fibrosis.
- liver cirrhosis /
- bone morphogenetic proteins /
- Smad proteins /
- transforming growth factor beta1 /
- review

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参考文献(25)

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