辅助性T淋巴细胞17在肝细胞癌发生发展中的作用

张飞飞; 陈辉; 闾军

doi:10.3969/j.issn.1001-5256.2016.08.046

辅助性T淋巴细胞17在肝细胞癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2016.08.046

1. 首都医科大学附属北京佑安医院肝病与肿瘤生物治疗科
2. 中国科学院动物研究所膜生物学国家重点实验室移植生物学研究组

基金项目:

北京市卫生系统高层次卫生技术人才培训资助项目(2011-2-20)； “十二五”重大科技专项基金资助项目(2014ZX10002002-001-002)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2016-03-10
- 出版日期: 2016-08-20

Role of T-helper cell 17 in the development and progression of hepatocellular carcinoma

Department of Hepatopathy and Cancer Biotherapy,Beijing You An Hospital,Capital Medical University

Research funding:

摘要

摘要:
肝细胞癌是世界上最常见的恶性肿瘤之一,对于如何提高肝细胞癌治愈率和降低其复发及转移一直是人们研究的重点。辅助性T淋巴细胞（Th）17是一种重要的CD4+Th亚型,在感染、自身免疫反应及肿瘤微环境中具有重要作用。介绍了Th17及其相关细胞因子的发现,归纳了其在肝细胞癌发生及进展过程中的作用机制及相关临床意义,为Th17在肝细胞癌治疗新靶点及判断预后方面提供一些见解。
- 癌,肝细胞 /
- T淋巴细胞亚群 /
- 综述
Abstract:
Hepatocellular carcinoma( HCC) is one of the most common malignant tumors in the world. How to improve cure rate and reduce recurrence and metastasis of HCC have always been hot topics in research. T- helper cell 17( Th17),an important subset of CD4+T-helper cells,plays a critical role in infection,autoimmune response,and tumor microenvironment. This article introduces the discovery of Th17 and related cytokines,summarizes its mechanisms of action and clinical significance in the development and progression of HCC,and provides some clues for new targets in the treatment of HCC and prognosis prediction.
- carcinoma /
- hepatocellular /
- T-lymphocyte subsets

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参考文献(36)

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