原发性胆汁性胆管炎乏力机制与治疗进展

赵健; 曹嘉; 姚定康

doi:10.3969/j.issn.1001-5256.2016.11.050

原发性胆汁性胆管炎乏力机制与治疗进展

DOI: 10.3969/j.issn.1001-5256.2016.11.050

第二军医大学附属长征医院内科学教研室

详细信息

中图分类号: R575.7
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出版历程
- 收稿日期: 2016-06-08
- 出版日期: 2016-11-20

Research advances in pathogenesis and management of fatigue in patients with primary biliary cirrhosis

Department of Internal Medicine,Changzheng Hospital,Second Military Medical University

摘要

摘要: 乏力是原发性胆汁性胆管炎(PBC)最常见的症状之一,严重影响患者的生活质量。其发病机制尚不清楚,也尚无明确有效的治疗方法。回顾了PBC乏力的发病机制与治疗的最新进展,研究表明PBC乏力病因包括大脑改变、睡眠障碍、抑郁、自主神经功能失调、肌肉代谢异常等多种中枢性与周围性因素;而莫达非尼治疗PBC乏力的疗效尚不确切。在PBC乏力的病因与治疗领域还需要深入的系统性研究。
- 肝硬化,胆汁性 /
- 疲劳 /
- 综述
Abstract: Fatigue is one of the most common symptoms of primary biliary cirrhosis( PBC) and greatly affects patients' quality of life. The pathogenesis of fatigue in PBC remains unknown and there are no effective therapeutic methods. This article reviews the latest advances in the pathogenesis and treatment of fatigue in PBC. Studies have shown that the causes of fatigue in PBC include various central and peripheral factors,such as the changes in the brain,sleep disorders,depression,autonomic nervous dysfunction,and abnormal muscle metabolism.Modafinil does not have a definite therapeutic effect in fatigue in PBC. The causes and treatment of fatigue in PBC still need in- depth systematic studies.
- liver cirrhosis,biliary /
- fatigue /
- review

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参考文献(38)

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