肿瘤坏死因子α诱导蛋白8样分子2在肝脏及胃肠道肿瘤发生发展中的作用

孔丽; 金萌; 赵素贤

doi:10.3969/j.issn.1001-5256.2017.01.041

肿瘤坏死因子α诱导蛋白8样分子2在肝脏及胃肠道肿瘤发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2017.01.041

1. 河北医科大学第三医院肝病科
2. 河北医科大学第三医院中医外科

基金项目:

河北省科技厅课题(2015043467)；河北省卫生厅课题(ZL20140032)；

详细信息

中图分类号: R735
计量
- 文章访问数: 2001
- HTML全文浏览量: 30
- PDF下载量: 418
- 被引次数: 0
出版历程
- 出版日期: 2017-01-20

Role of tumor necrosis factor- alpha- induced protein 8-like 2 in development and progression of liver and gastrointestinal tumors

Department of Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Research funding:

摘要

摘要:
肝脏及胃肠道肿瘤是严重影响人类健康的恶性疾病,治疗效果及预后差。肿瘤坏死因子α诱导蛋白8样分子2(TIPE2)可负性调控固有免疫和适应性免疫,具有维持免疫稳态的作用。近年来发现TIPE2可通过影响多条信号通路,在肿瘤的发生发展中发挥抑制作用。简述了TIPE2的结构及功能,介绍了TIPE2对Ras、Ral、Rac等肿瘤相关信号通路及其下游分子的调控作用,并对TIPE2在肝脏及胃肠道肿瘤中的作用及相关信号通路、研究进展进行了总结。
- 肝肿瘤 /
- 胃肿瘤 /
- 肠肿瘤 /
- 肿瘤坏死因子α诱导蛋白8样分子2 /
- 综述
Abstract:
Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis. Tumor necrosis factor- alpha- induced protein 8- like 2( TIPE2) can negatively regulate innate immunity and adaptive immunity and maintain immune homeostasis. Recent studies have found that TIPE2 can affect various signaling pathways and thus exerts an inhibitory effect on the development and progression of tumors. This article briefly introduces the structure and function of TIPE2 and its regulatory effect on tumor- related signaling pathways such as Ras,Ral,and Rac and downstream molecules,as well as the role of TIPE2 in liver and gastrointestinal tumors,related signaling pathways,and research advances.
- liver neoplasms /
- stomach neoplasms /
- intestinal neoplasms /
- tumor necrosis factor-alpha-induced protein 8-like 2 /
- review

HTML全文

参考文献(34)

[1]SUN H,GONG S,CARMODY RJ,et al.TIPE2,a negative regulator of innate and adaptive immunity that maintains immune homeostasis[J].Cell,2008,133(3):415-426.

[2]LI D,SONG L,FAN Y,et al.Down regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus[J].Clin Immunol,2009,133(3):422-427.

[3]XI W,HU Y,LIU Y,et al.Roles of TIPE2 in hepatitis B virusinduced hepatic inflammation in humans and mice[J].Mol Immunol,2011,48(9-10):1203-1208.

[4]WANG LY,FAN YC,ZHAO J,et al.Elevated expression of tumour necrosis factor-α-induced protein 8(TNFAIP8)-like 2mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure[J].J Viral Hepat,2014,21(1):64-73.

[5]KONG L,LIU K,ZHANG YZ,et al.Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with chronic hepatitis C[J].Hepatol Int,2013,7(3):844-849.

[6]GUS-BRAUTBAR Y,JOHNSON D,ZHANG L,et al.The Anti-inflammatory TIPE2 is an inhibitor of the oncogenic ras[J].Molecular Cell,2012,45(5):610-618.

[7]ZHANG X,WANG J,FAN C,et al.Crystal structure of TIPE2 provides insights into immune homeostasis[J].Nat Strcct Mol Biol,2009,16(1):89-90.

[8]LUAN YY,YAO RQ,TONG S,et al.Effect of tumor necrosis factor-αinduced protein 8 like-2 on immune function of dendritic cells in mice following acute insults[J].Oncotarget,2016,7(21):30178-30192.

[9]LUAN YY,YAO YM,ZHANG L,et al.Expression of tumor necrosis factor-induced protein8 like-2 contributes to the immunosuppressive property of CD4+CD25+regulatory T cells in mice[J].Mol Immunol,2011,49(1-2):219-226.

[10]SUN H,ZHUANG G,CHAI L,et al.TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway[J].J Immunol,2012,189(6):2768-2773.

[11]WANG Z,FAYNGERTS S,WANG P,et al.TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection[J].Proc Natl Acad Sci U S A,2012,109(38):15413-15418.

[12]ZHANG G,HAO C,LOU Y,et al.Tissue-specific expression of TIPE2 provides insights into its function[J].Mol Immunol,2010,47(15):2435-2442.

[13]ZHANG L,SHI Y,WANG Y,et al.The unique expression profile of human TIPE2 suggests new functions beyond its role in immune regulation[J].Mol Immunol,2011,48(9-10):1209-1215.

[14]SUO LG,CUI YY,BAI Y,et al.Anti-inflammatory TIPE2 inhibits angiogenic VEGF in retinal pigment epithelium[J].Mol Immunol,2016,73:46-52.

[15]LI X.TIPE2 regulates tumor-associated macrophages in skin squamous cell carcinoma[J].Tumour Biol,2016,37(4):5585-5590.

[16]LIU QQ,ZHANG FF,WANG F,et al.TIPE2 inhibits lung cancer growth attributing to promotion of apoptosis by regulating some apoptotic molecules expression[J].PLo S One,2015,10(5):e0126176.

[17]LI Y,LI X,LIU G,et al.Downregulated TIPE2 is associated with poor prognosis and promotes cell proliferation in non-small cell lung cancer[J].Biochem Biophys Res Commun,2015,457(1):43-49.

[18]REN CZ,HAO LS.Signal transduction involved in activation of hepatic stellate cells[J].J Clin Hepatol,2015,31(3):452-456.(in Chinese)任昌镇,郝礼森.肝星状细胞活化过程中的信号转导[J].临床肝胆病杂志,2015,31(3):452-456.

[19]FERRO E,TRABALZINI L.Ral GDS family members couple Ras to Ral signalling and that's not all[J].Cell Signal,2010,22(12):1804-1810.

[20]MIREY G,BALAKIREVA M,L'HOSTE S,et al.A Ral guanine exchange factor-Ral pathway is conserved in drosophila melanogaster and sheds new light on the connectivity of the Ral,Ras,and Rap pathways[J].Mol Cell Biol,2003,23(3):1112-1124.

[21]YIN J,POLLOCK C,TRACY K,et al.Activation of the Ral GEF/Ral pathway promotes prostate cancer metastasis to bone[J].Mol Cell Biol,2007,27(21):7538-7550.

[22]HAO Y,WONG R,FEIG LA.Ral GDS couples growth factor signaling to Akt activation[J].Mol Cell Biol,2008,28(9):2851-2859.

[23]MOSKALENKO S,HENRY DO,ROSSE C,et al.The exocyst is a Ral effector complex[J].Nat Cell Biol,2002,4(1):66-72.

[24]HE B,GUO W.The exocyst complex in polarized exocytosis[J].Curr Opin Cell Biol,2009,21(4):537-542.

[25]MOSKALENKO S,TONG C,ROSSE C,et al.Ral GTPases regulate exocyst assembly through dual subunit interactions[J].J Biol Chem,2003,278(51):51743-51748.

[26]CAO X,ZHANG L,SHI Y,et al.Human tumor necrosis factor(TNF)-alpha induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1[J].Mol Cancer,2013,12(1):149-158.

[27]ZHANG YH,YAN HQ,WANG F,et al.TIPE2 inhibits TNF-α-induced hepatocellular carcinoma cell metastasis via Erk1/2downregulation and NF-κB activation[J].Int J Oncol,2015,46(1):254-264.

[28]PENG Y,ZHAO Q,ZHANG H,et al.TIPE2,a negative regulator of TLR signaling,regulates p27 through IRF4-induced signaling[J].Oncol Rep,2016,35(4):2480-2486.

[29]ZHAO Q,ZHAO M,DONG T,et al.Tumor necrosis factor-α-induced protein-8 like-2(TIPE2)upregulates p27 to decrease gastic cancer cell proliferation[J].J Cell Biochem,2015,116(6):1121-1129.

[30]ZHU Y,TAO M,WU J,et al.Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling[J].Cancer Gene Ther,2016,23(4):98-106.

[31]WU J,ZHANG H,XU C,et al.TIPE2 functions as a metastasis suppressor via negatively regulatingβ-catenin through activating GSK3βin gastric cancer[J].Int J Oncol,2016,48(1):199-206.

[32]YANG TT,CHENG ZL,LI XM,et al.Expression of tumor necrosis factor-α-induced protein 8-like 2 in colon cancer and precancerous disease and its significance[J].Chin J Dig,2011,31(5):341-343.(in Chinese)杨廷廷,程兆令,李雪梅,等.肿瘤坏死因子α诱导蛋白8样因子2在结肠癌及癌前疾病中的表达及意义[J].中华消化杂志,2011,31(5):341-343.

[33]LI XM,YAN SP,SU JR,et al.Role and molecular mechanism of TIPE2 in the progression of colon cancer[J].J Shandong Univ:Health Sciences,2014,52(1):20-22.(in Chinese)李雪梅,颜世平,宿敬然,等.TIPE2在结肠癌发展中的作用及分子机制[J].山东大学学报:医学版,2014,52(1):20-22.

[34]LI XM,SU JR,YAN SP,et al.A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8[J].Cancer Biomark,2014,14(4):233-240.

施引文献

资源附件(0)

访问统计