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AFP、CA19-9、CEA联合检测对原发性肝癌的早期诊断价值

李嘉妍 宋金云 王建芳 吴旭平

引用本文:
Citation:

AFP、CA19-9、CEA联合检测对原发性肝癌的早期诊断价值

DOI: 10.3969/j.issn.1001-5256.2017.07.017
详细信息
  • 中图分类号: R735.7

Value of combined detection of AFP, CA19-9, and CEA in early diagnosis of primary liver cancer

  • 摘要: 目的研究AFP、CA19-9、CEA联合检测对原发性肝癌进行早期诊断的临床价值。方法收集2014年10月-2016年12月东南大学附属第二医院门诊和住院的肝病患者248例,分为原发性肝癌组(n=88)和非肿瘤性肝病组(n=160),另选取130例健康体检者为正常对照组。采用Roche cobas e 411 analyzer检测3组患者的血清肿瘤标志物AFP、CA19-9、CEA水平,分析3种肿瘤标志物单个检测和联合检测的灵敏度和特异度。采用Beckman Coulter AU5800检测肝功能生化指标。采用Biotek ELX808检测HBV血清学标志物和HCV抗体。应用受试者工作特征曲线(ROC曲线)对原发性肝癌患者的血清AFP、CA19-9、CEA及3者联合检测结果进行分析评价。计量资料多组间比较采用单因素方差分析,进一步两两比较采用SNK-q检验,2组间比较采用t检验;计数资料组间比较采用χ2检验。相关性分析采用Spearman分析。结果在原发性肝癌组和非肿瘤性肝病组中,肝功能异常患者的AFP、CA19-9均显著高于肝功能正常组(原发性肝癌组:t值分别为3...

     

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  • 收稿日期:  2016-12-01
  • 出版日期:  2017-07-20
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