肝硬化肌肉痉挛的治疗进展

赵文姗; 尤红; 赵新颜

doi:10.3969/j.issn.1001-5256.2017.10.033

肝硬化肌肉痉挛的治疗进展

DOI: 10.3969/j.issn.1001-5256.2017.10.033

首都医科大学附属北京友谊医院肝病中心

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中图分类号: R575.2
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出版历程
- 收稿日期: 2017-04-06
- 出版日期: 2017-10-20

Advances in treatment of muscle cramp in liver cirrhosis

Liver Research Center, Beijing Friendship Hospital, Capital Medical University

摘要

摘要: 肌肉痉挛是肝硬化患者的常见临床症状之一,严重影响患者生活质量。关于肝硬化的研究多集中在病因及常见并发症的治疗和预防,针对合并肌肉痉挛的治疗研究相对较少,因此寻找安全有效的治疗方案是非常重要的。简述了肝硬化患者出现肌肉痉挛的发病机制以及相关表现,并对当前具有临床应用价值的多种治疗方案进行总结,包括氯苯氨丁酸、左卡尼汀以及牛磺酸等新型治疗药物,并通过牛磺酸对细胞外基质以及肝星状细胞的活化作用进一步阐述对肝纤维化的保护作用,以期为肝硬化时肌肉痉挛的治疗提供新证据。
- 肝硬化 /
- 肌肉痉挛 /
- 治疗 /
- 综述
Abstract: Muscle cramp is one of the common symptoms of patients with liver cirrhosis and significantly affects patients' quality of life. In general, the research on liver cirrhosis mainly focuses on the management and prevention of causes or common complications, and there are relatively few studies on the treatment of muscle cramp. Therefore, it is very important to find safe and effective therapeutic regimens. This article describes the pathogenesis and manifestations of muscle cramp in patients with liver cirrhosis, summarizes the therapeutic regimens with clinical value, including new drugs such as baclofen, L-carnitine, and taurine, and further elaborates on the protective effect of taurine against liver fibrosis via its activation of extracellular matrix and hepatic stellate cells, in order to provide new evidence for the treatment of muscle cramp in liver cirrhosis.
- liver cirrhosis /
- muscle cramps /
- therapy /
- review

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参考文献(20)

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