血小板在慢性肝病中的研究现状

林岩; 李汛

doi:10.3969/j.issn.1001-5256.2017.11.043

血小板在慢性肝病中的研究现状

DOI: 10.3969/j.issn.1001-5256.2017.11.043

林岩,
李汛

1. 兰州大学第一临床医学院
2. 兰州大学第一医院普外五科

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2017-05-09
- 出版日期: 2017-11-20

Research advances in the role of platelets in liver diseases

Lin Yan,
Li Xun

The First Clinical Medical College of Lanzhou University

摘要

摘要: 肝纤维化、肝硬化等慢性肝病的机制较为复杂,是肝内各种细胞、细胞因子、基质相互作用的结果。传统观点认为血小板的主要功能是参与止血和凝血。最近研究认为血小板不仅含有止血所需要的分子蛋白质,且富含器官发育、组织再生和修复的生长因子,而且与肝纤维化、肝硬化等慢性肝病的发生发展及肝组织再生过程关系密切,在肝内稳态和病理中发挥关键作用。对血小板在慢性肝病中的作用进行阐述,认为血小板与肝纤维化、肝再生的信号通路等方面的关系已获得诸多研究结果,未来血小板可能成为治疗慢性肝病的新的重要靶点。
- 血小板 /
- 肝疾病 /
- 综述
Abstract: Chronic liver diseases such as liver fibrosis and liver cirrhosis have a complex pathogenesis and are the result of interaction between various cells, cytokines, and matrix in the liver.The traditional viewpoints believe that platelets are mainly involved in hemostasis and coagulation.In recent years, more and more articles have reported that platelets contain molecular protein for hemostasis and growth factors for organ development and tissue regeneration/repair;moreover, platelets are closely associated with the development and progression of chronic liver diseases such as liver fibrosis and liver cirrhosis and regeneration of liver tissue.They also play a key role in liver homeostasis and pathology.At present, many research findings have been achieved in the association between platelets and the signaling pathways of liver fibrosis and liver regeneration, suggesting that platelets may become a new target for the treatment of chronic liver diseases.
- blood platelets /
- liver diseases /
- review

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参考文献(34)

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