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445例药物性肝损伤的临床分析

朱春雾 王海南 袁继丽 彭渊 张亚蕾 薛冬英 张琴 刘成海

引用本文:
Citation:

445例药物性肝损伤的临床分析

DOI: 10.3969/j.issn.1001-5256.2018.02.027
基金项目: 

上海市三年行动计划(ZY3-CCCX-2-1003); 

详细信息
  • 中图分类号: R575

Clinical features of drug-induced liver injury: an analysis of 445 cases

Research funding: 

 

  • 摘要:

    目的描述性分析药物性肝损伤(DILI)的临床特征。方法回顾性收集2012年1月-2016年12月在上海中医药大学附属曙光医院、上海中医药大学附属普陀医院、上海交通大学医学院附属同仁医院诊断为DILI的445例患者的病史、症状体征、检查结果、治疗与转归等临床资料,分析DILI的临床特征。计量资料以中位数和四分位数间距[M(P25P75)]表示,组间比较采用Kruskal-Wallis H检验;计数资料组间比较采用χ2检验。结果 445例患者中,男136例(30.56%),女309例(69.44%),以4069岁的人群居多。194例(43.6%)应用西药导致,140例(31.46%)应用中药导致,中西药联用者92例(20.67%),服用保健品者19例(4.27%)。引起肝损伤的中药主要有何首乌及其制剂、仙灵骨葆胶囊、癃闭舒胶囊等;导致肝损伤的西药主要有心血管用药、抗微生物用药、解热镇痛药、抗肿瘤用药、抗结核药等。临床症状主要有乏力、纳差、黄疸、恶心等,其中以乏力(65.17%)最常见。临床分型主要为肝细胞损伤型,占70.11...

     

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  • 出版日期:  2018-02-20
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