秋水仙碱致伴有自身免疫现象的药物性肝损伤1例报告

陈晓倩; 张凤; 王志宇; 蔡艳俊; 齐月

doi:10.3969/j.issn.1001-5256.2018.02.034

秋水仙碱致伴有自身免疫现象的药物性肝损伤1例报告

DOI: 10.3969/j.issn.1001-5256.2018.02.034

吉林大学第一医院肝病科

基金项目:

中国肝炎防治基金会王宝恩肝纤维化研究基金(CFHPC20131053)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2018-02-20

Colchicine-induced liver injury with autoimmune features: a case report

Department of Hepatology, The First Hospital of Jilin University

Research funding:

摘要

摘要:
<正>秋水仙碱是一种生物碱,能抑制中性粒细胞的趋化、黏附和吞噬作用及抑制局部细胞产生白介素-6等,可控制关节局部的疼痛、肿胀及炎症反应。临床中广泛应用于痛风性关节炎的治疗,主要通过肝肾代谢。常见的不良反应多表现为胃肠道反应,骨髓抑制等,常规剂量情况下引起严重的药物性肝损伤（DILI）较少见。本例患者因常规剂量口服秋水仙碱片4 d后,出现伴有自身免疫现象的DILI合并多脏器功能障碍,现报道
- 药物性肝损伤 /
- 秋水仙碱 /
- 干燥综合征 /
- 自身免疫疾病 /
- 病例报告
- drug induced liver injury /
- colchicine /
- sjogren's syndrome /
- autoimmune features /
- case reports

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参考文献(25)

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