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HCV感染与动脉粥样硬化的关系

赵健 魏博 梁春

引用本文:
Citation:

HCV感染与动脉粥样硬化的关系

DOI: 10.3969/j.issn.1001-5256.2018.02.042
详细信息
  • 中图分类号: R512.63

Association between hepatitis C virus infection and atherosclerosis

  • 摘要:

    慢性感染和炎症反应与动脉粥样硬化的发生相关,而HCV感染是较为常见的感染性疾病。回顾了HCV感染与动脉粥样硬化相关疾病发生关系的最新进展,研究表明更多的证据支持HCV感染会增加冠心病、卒中、颈动脉粥样硬化的发生率以及因心血管事件的死亡风险。HCV感染是动脉粥样硬化的危险因素,虽然背后的机制尚需更多研究,但在丙型肝炎患者人群中应注意预防与控制动脉粥样硬化性疾病。

     

  • [1]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for hepatitis C:a 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1961-1979. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.丙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1961-1979.
    [2]YOUNOSSI Z, PARK H, HENRY L, et al.Extrahepatic manifestations of hepatitis C:a meta-analysis of prevalence, quality of life, and economic burden[J].Gastroenterology, 2016, 150 (7) :1599-1608.
    [3]SANDER D, WINBECK K, KLINGELHOFER J, et al.Reduced progression of early carotid atherosclerosis after antibiotic treatment and Chlamydia pneumoniae seropositivity[J].Circulation, 2002, 106 (19) :2428-2433.
    [4]ISHIZAKA N, ISHIZAKA Y, TAKAHASHI E, et al.Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening[J].Lancet, 2002, 359 (9301) :133-135.
    [5]DAI CY, CHUANG WL, HO CK, et al.Associations between hepatitis C viremia and low serum triglyceride and cholesterol levels:a community-based study[J].J Hepatol, 2008, 49 (1) :9-16.
    [6]LIN MS, GUO SE, CHEN MY, et al.The impact of hepatitis C infection on ischemic heart disease via ischemic electrocardiogram[J].Am J Med Sci, 2014, 347 (6) :478-484.
    [7]BUTT AA, XIAOQIANG W, BUDOFF M, et al.Hepatitis C virus infection and the risk of coronary disease[J].Clin Infect Dis, 2009, 49 (2) :225-232.
    [8]TSUI JI, WHOOLEY MA, MONTO A, et al.Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease:data from the Heart and Soul study[J].J Card Fail, 2009, 15 (5) :451-456.
    [9]FORDE KA, HAYNES K, TROXEL AB, et al.Risk of myocardial infarction associated with chronic hepatitis C virus infection:a population-based cohort study[J].J Viral Hepat, 2012, 19 (4) :271-277.
    [10]AMBROSINO P, LUPOLI R, DI MINNO A, et al.The risk of coronary artery disease and cerebrovascular disease in patients with hepatitis C:a systematic review and meta-analysis[J].Int J Cardiol, 2016, 221:746-754.
    [11]LEE MH, YANG HI, WANG CH, et al.Hepatitis C virus infection and increased risk of cerebrovascular disease[J].Stroke, 2010, 41 (12) :2894-2900.
    [12]ADINOLFI LE, RESTIVO L, ZAMPINO R, et al.Chronic HCV infection is a risk of atherosclerosis.Role of HCV and HCV-related steatosis[J].Atherosclerosis, 2012, 221 (2) :496-502.
    [13]LIAO CC, SU TC, SUNG FC, et al.Does hepatitis C virus infection increase risk for stroke?A population-based cohort study[J].PLo S One, 2012, 7 (2) :e31527.
    [14]HSU CS, KAO JH, CHAO YC, et al.Interferon-based therapy reduces risk of stroke in chronic hepatitis C patients:a populationbased cohort study in Taiwan[J].Aliment Pharmacol Ther, 2013, 38 (4) :415-423.
    [15]BARAKAT AA, NASR FM, METWALY AA, et al.Atherosclerosis in chronic hepatitis C virus patients with and without liver cirrhosis[J].Egyptian Heart J, 2017, 69 (2) :139-147.
    [16]KIECHL S, EGGER G, MAYR M, et al.Chronic infections and the risk of carotid atherosclerosis:prospective results from a large population study[J].Circulation, 2001, 103 (8) :1064-1070.
    [17]MIYAJIMA I, KAWAGUCHI T, FUKAMI A, et al.Chronic HCV infection was associated with severe insulin resistance and mild atherosclerosis:a population-based study in an HCV hyperendemic area[J].J Gastroenterol, 2013, 48 (1) :93-100.
    [18]ASLAM F, ALAM M, LAKKIS NM.Hepatitis C and carotid atherosclerosis:a retrospective analysis[J].Atherosclerosis, 2010, 209 (2) :340-343.
    [19]OLUBAMWO OO, ONYEKA IN, MIETTOLA J, et al.Hepatitis C as a risk factor for carotid atherosclerosis-a systematic review[J].Clin Physiol Funct Imaging, 2016, 36 (4) :249-260.
    [20]PETTA S, TORRES D, FAZIO G, et al.Carotid atherosclerosis and chronic hepatitis C:a prospective study of risk associations[J].Hepatology, 2012, 55 (5) :1317-1323.
    [21]MOSTAFA A, MOHAMED MK, SAEED M, et al.Hepatitis C infection and clearance:impact on atherosclerosis and cardiometabolic risk factors[J].Gut, 2010, 59 (8) :1135-1140.
    [22]AMIN J, LAW MG, BARTLETT M, et al.Causes of death after diagnosis of hepatitis B or hepatitis C infection:a large community-based linkage study[J].Lancet, 2006, 368 (9539) :938-945.
    [23]GUILTINAN AM, KAIDAROVA Z, CUSTER B, et al.Increased allcause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors[J].Am J Epidemiol, 2008, 167 (6) :743-750.
    [24]VOLZKE H, SCHWAHN C, WOLFF B, et al.Hepatitis B and C virus infection and the risk of atherosclerosis in a general population[J].Atherosclerosis, 2004, 174 (1) :99-103.
    [25]PETTA S, MAIDA M, MACALUSO FS, et al.Hepatitis C virus infection is associated with increased cardiovascular mortality:a meta-analysis of observational studies[J].Gastroenterology, 2016, 150 (1) :145-155, e15-e16.
    [26]BODDI M, ABBATE R, CHELLINI B, et al.Hepatitis C virus RNA localization in human carotid plaques[J].J Clin Virol, 2010, 47 (1) :72-75.
    [27]FLETCHER NF, WILSON GK, MURRAY J, et al.Hepatitis C virus infects the endothelial cells of the blood-brain barrier[J].Gastroenterology, 2012, 142 (3) :634-643.
    [28]KANG RQ, CHEN HY.Relationship between fatty liver disease and carotid atherosclerosis in college teachers[J/CD].Chin J Liver Dis:Electronic Edition, 2016, 8 (1) :100-102. (in Chinese) 康荣芹, 陈红艳.高校教师脂肪肝与颈动脉粥样硬化相关性分析[J/CD].中国肝脏病杂志:电子版, 2016, 8 (1) :100-102.
    [29]LIU DJ, CHEN QF.Pathogenesis of insulin resistance and its impact on antiviral therapy in patients with chronic hepatitis C[J].J Clin Hepatol, 2017, 33 (6) :1152-1155. (in Chinese) 刘大吉, 陈青锋.慢性丙型肝炎患者胰岛素抵抗的发病机制及对抗病毒治疗的影响[J].临床肝胆病杂志, 2017, 33 (6) :1152-1155.
    [30]BANKS DE, BOGLER Y, BHUKET T, et al.Significant disparities in risks of diabetes mellitus and metabolic syndrome among chronic hepatitis C virus patients in the U.S[J].Diabetes Metab Syndr, 2016.[Epub ahead of print]
    [31]NAHON P, BOURCIER V, LAYESE R, et al.Eradication of hepatitis C virus infection in patients with cirrhosis reduces risk of liver and non-liver complications[J].Gastroenterology, 2017, 152 (1) :142-156.
    [32]van der MEER AJ, VELDT BJ, FELD JJ, et al.Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis[J].JAMA, 2012, 308 (24) :2584-2593.
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  • 出版日期:  2018-02-20
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