我国药物性肝损伤流行病学研究现状

沈弢; 黄昕; 王誉雅; 庄辉

doi:10.3969/j.issn.1001-5256.2018.06.002

我国药物性肝损伤流行病学研究现状

DOI: 10.3969/j.issn.1001-5256.2018.06.002

北京大学医学部基础医学院

详细信息

中图分类号: R181.3;R575
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出版历程
- 收稿日期: 2018-03-31
- 出版日期: 2018-06-20

Current status of epidemiological studies on drug-induced liver injury in China

School of Basic Medical Sciences, Peking University Health Science Center

摘要

摘要: 药物性肝损伤(DILI)的重要性已越来越多地引起政府医药主管部门、制药公司、临床工作者以及普通公众的重视。了解我国DILI的发生率、分布、常见诱发药物等流行病学特征,有助于DILI的预防、临床诊断和治疗,也有助于政府完善有关法规,降低药物不良反应的发生。现就我国DILI的流行病学现状作一阐述。
- 药物性肝损伤 /
- 中草药 /
- 抗结核药 /
- 流行病学
Abstract: Drug-induced liver injury (DILI) has been taken more and more seriously by governmental authorities, pharmaceutical companies, clinical physicians, and the general public. An understanding of the incidence, and distribution of DILI and related drugs is helpful for the prevention, clinical diagnosis, and treatment of DILI and may also help the government to perfect related laws and regulations and reduce the incidence of adverse drug reactions. This article reviews the epidemiology of DILI in China.
- drug-induced liver diseases /
- drugs, Chinese herbal /
- antitubercular agents /
- epidemiology

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参考文献(29)

[1]BJORNSSON E, JERLSTAD P, BERGQVIST A, et al.Fulminant drug-induced hepatic failure leading to death or liver transplantation in Sweden[J].Scand J Gastroenterol, 2005, 40 (9) :1095-1101.

[2]OHMORI S, SHIRAKI K, INOUE H, et al.Clinical characteristics and prognostic indicators of drug-induced fulminant hepatic failure[J].Hepatogastroenterology, 2003, 50 (53) :1531-1534.

[3]OSTAPOWICZ G, FONTANA RJ, SCHIODT FV, et al.Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States[J].Ann Intern Med, 2002, 137 (12) :947-954.

[4]REUBEN A, KOCH DG, LEE WM.Drug-induced acute liver failure:Results of a U.S.multicenter, prospective study[J].Hepatology, 2010, 52 (6) :2065-2076.

[5]RUSSO MW, GALANKO JA, SHRESTHA R, et al.Liver transplantation for acute liver failure from drug induced liver injury in the United States[J].Liver Transpl, 2004, 10 (8) :1018-1023.

[6]WEI G, BERGQUIST A, BROOME U, et al.Acute liver failure in Sweden:Etiology and outcome[J].J Intern Med, 2007, 262 (3) :393-401.

[7]BJORNSSON ES, BERGMANN OM, BJORNSSON HK, et al.Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland[J].Gastroenterology, 2013, 144 (7) :1419-1425, 25 e1-e3;quiz e19-e20.

[8]SGRO C, CLINARD F, OUAZIR K, et al.Incidence of drug-induced hepatic injuries:A French population-based study[J].Hepatology, 2002, 36 (2) :451-455.

[9] SHEN T, MAO YM, CHEN CW.An epidemiological study of drug-induced liver injury in China[R].The Fourth National Academic Conference on Drug-induced Liver Injury, 2017. (in Chinese) 沈弢, 茅益民, 陈成伟.中国DILI流行病学研究[R].第四届全国药物性肝损伤学术会议, 2017.

[10]CHENG CY, WANG S, ZHANG YH.37 clinical reports of drug-induced liver diseases[J].Chongqing Med J, 1999, 28 (3) :198-199. (in Chinese) 程朝英, 王莎, 张姚衡.药物性肝损害37例临床分析[J].重庆医学, 1999, 28 (3) :198-199.

[11]ZHOU HJ, LI SG.103 clinical reports of drug-induced liver diseases[J].Chin J Clin Pharm, 2001, 10 (5) :291-293. (in Chinese) 周华坚, 李韶光.药物性肝损害103例临床分析[J].中国临床药学杂志, 2001, 10 (5) :291-293.

[12]GUAN YJ, XIAN JZ, TANG XP, et al.Clinical analysis of drug-induced liver disease in 191 patients[J].Chin J Hepatol, 2003, 11 (7) :390. (in Chinese) 关玉娟, 冼建中, 唐小平, 等.191例药物性肝病患者的临床分析[J].中华肝脏病杂志, 2003, 11 (7) :390.

[13]ZHOU SM, JIA J.Clinical analysis of 96 patients with traditional Chinese medicine-induced liver diseases[J].China Trop Med, 2004, 4 (5) :765-766. (in Chinese) 周世明, 贾杰.中草药致药性肝病96例临床分析[J].中国热带医学, 2004, 4 (5) :765-766.

[14]SHANG J, XU Y, YANG YX, et al.Preliminary clinical study on drug-induced liver lesions in 104 patients[J].Chin J Hepatol, 2004, 12 (11) :694. (in Chinese) 尚佳, 徐芸, 杨玉秀, 等.药物性肝病104例临床分析[J].中华肝脏病杂志, 2004, 12 (11) :694.

[15]Cooperative Group of Hepatobiliary Disease of Digestive Disease Branch of Chinese Medical Association.A multicenter survey on hospital inpatients with drug-induced acute liver injury in China[J].Chin J Dig, 2007, 27 (7) :439-442. (in Chinese) 中华医学会消化病学分会肝胆疾病协作组.全国多中心急性药物性肝损伤住院病例调研分析[J].中华消化杂志, 2007, 27 (7) :439-442.

[16]LI L, JIANG W, WANG JY, et al.Clinical analysis of acute drug-induced liver disease in 275 cases[J].J Clin Hepatol, 2009, 25 (1) :44-46. (in Chinese) 李蕾, 蒋炜, 王吉耀, 等.275例急性药物性肝病临床分析[J].临床肝胆病杂志, 2009, 25 (1) :44-46.

[17]YNAG LX.Clinical analysis of 248 cases of drug induced liver diseases[J].Chin J Gastroenterol Hepatol, 2012, 21 (3) :261-263. (in Chinese) 杨立新.药物性肝病248例临床分析[J].胃肠病学和肝病学杂志, 2012, 21 (3) :261-263.

[18] CAI Y.Clinical analysis of 120 cases of drug induced liver diseases[J].China Health Nutrition, 2014, 24 (7) :3764-3765. (in Chinese) 柴颖.药物性肝病120例临床分析[J].中国保健营养, 2014, 24 (7) :3764-3765.

[19]LAI RT, WANG H, GUI HL, et al.Clinical and pathological features in 138 cases of drug-induced liver injury[J].Chin J Hepatol, 2012, 20 (3) :185-189. (in Chinese) 赖荣陶, 王晖, 桂红莲, 等.138例药物性肝损伤患者的临床特征及肝脏组织学改变[J].中华肝脏病杂志, 2012, 20 (3) :185-189.

[20]WAI CT.Presentation of drug-induced liver injury in Singapore[J].Singapore Med J, 2006, 47 (2) :116-120.

[21]ZHOU Y, YANG L, LIAO Z, et al.Epidemiology of drug-induced liver injury in China:A systematic analysis of the Chinese literature including 21, 789 patients[J].Eur J Gastroenterol Hepatol, 2013, 25 (7) :825-829.

[22]YE DM, LAN S, MENG SY.Drug treatment of drug-induced liver injury:Analysis for 262 cases[J].Eval Anal Drug-Use Hosp China, 2010, 10 (8) :754-757. (in Chinese) 叶冬梅, 兰顺, 蒙石英.262例药源性肝损害病例的药物治疗分析[J].中国医院用药评价与分析, 2010, 10 (8) :754-757.

[23]WU YS, ZHENG QK, LI YL, et al.A review of drug-induced liver damage in 509 cases[J].ADRJ, 2002, 4 (6) :364-368. (in Chinese) 吴苑珊, 郑企琨, 黎月玲, 等.509例药源性肝损害文献分析[J].药物不良反应杂志, 2002, 4 (6) :364-368.

[24]WANG M.Chinese medicine induced liver damage[J].Chin J Misdiagn, 2006, 6 (7) :1388-1389. (in Chinese) 王敏.中药致药源性肝损害[J].中国误诊学杂志, 2006, 6 (7) :1388-1389.

[25]XUE GX.Chinese Medicine clinical review of hepatic lesion[J].Pract Tradit Chin Intern Med, 2010, 24 (8) :81-82. (in Chinese) 薛国新.中药致肝损害的临床回顾[J].实用中医内科杂志, 2010, 24 (8) :81-82.

[26]LI JJ.Study on hepatotoxicity of traditional Chinese medicine[J].Hubei J Tradit Chin Med, 2012, 34 (8) :73-74. (in Chinese) 李江健.中药肝毒性的探讨[J].湖北中医杂志, 2012, 34 (8) :73-74.

[27] CHALASANI NP, HAYASHI PH, BONKOVSKY HL, et al.ACG Clinical Guideline:The diagnosis and management of idiosyncratic drug-induced liver injury[J].Am J Gastroenterol, 2014, 109 (7) :950-966;quiz 67.

[28]World Health Organization.Global tuberculosis report 2016[R].Geneva, Switzerland:WHO Report 2016.

[29]ZHAO Y, XU S, WANG L, et al.National survey of drug-resistant tuberculosis in China[J].N Engl J Med, 2012, 366 (23) :2161-2170.

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