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抗线粒体抗体阴性原发性胆汁性胆管炎1例报告

张丽霞 黄絮 孙小杰 张颖 卢莎莎 史晓东 季慧范 郭晓林

引用本文:
Citation:

抗线粒体抗体阴性原发性胆汁性胆管炎1例报告

DOI: 10.3969/j.issn.1001-5256.2019.01.038
详细信息
  • 中图分类号: R575.7

A case of antimitochondrial antibody-negative primary biliary cholangitis

  • 摘要:

    <正>随着临床医生对原发性胆汁性胆管炎(PBC)认识的不断加深以及抗线粒体抗体(AMA)检测技术的广泛应用,我国被检出PBC病例数呈不断上升趋势。但PBC起病隐匿,早期无特异性症状,首诊误诊率仍高达70%,尤其是AMA阴性者。现报道1例高滴度抗平滑肌抗体(SMA)的AMA阴性PBC,以提高

     

  • [1]Chinese Society of Hepatology, Chinese Medical Association;Chinese Society of Gastroenterology, Chinese Medical Association;Chinese Society of Infectious Diseases, Chinese Medical Association.Consensus on the diagnosis and management of primary biliary cirrhosis (cholangitis) (2015) [J].J Clin Hepatol, 2015, 31 (12) :1980-1988. (in Chinese) 中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会.原发性胆汁性肝硬化 (又名原发性胆汁性胆管炎) 诊断和治疗共识 (2015) [J].临床肝胆病杂志, 2015, 31 (12) :1980-1988.
    [2]HIRSCHFIELD GM, DYSON JK, ALEXANDER GJM, et al.The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines[J].Gut, 2018, 67 (9) :1568-1594.
    [3]ZHANG FK, JIA JD, QIAN LX, et al.Clinical evaluation of serum anti-mitochondrial antibody-negative primary biliary cirrhosis[J].Chin Hepatol, 2002, 7 (3) :150-152. (in Chinese) 张福奎, 贾继东, 钱林学, 等.抗线粒体抗体阴性原发性胆汁性肝硬化的临床特征[J].肝脏, 2002, 7 (3) :150-152.
    [4]LI HB, FU HY, LU TY, et al.Important progress in the field of liver transplantation in 2017[J].Organ Transplantation, 2018, 9 (1) :41-50, 82. (in Chinese) 李海波, 符洪源, 陆桐宇, 等.肝移植领域2017年度重要进展盘点[J].器官移植, 2018, 9 (1) :41-50, 82.
    [5]GERSHWIN ME, SELMI C, WORMAN HJ, et al.Risk factors and comorbidities in primary biliary cirrhosis:A controlled interview-based study of 1032 patients[J].Hepatology, 2005, 42 (5) :1194-1202.
    [6]PRINCE MI, DUCKER SJ, JAMES OFW, et al.Case-control studies of risk factors for primary biliary cirrhosis in two United Kingdom populations[J].Gut Online, 2010, 59 (4) :508-512.
    [7]WANG YQ, FAN JG, SHEN F, et al.Systemic analysis of causes of misdiagnosis on primary biliary cirrhosis in China[J].JPract Med, 2012, 28 (11) :1894-1896. (in Chinese) 汪余勤, 范建高, 沈峰, 等.中国原发性胆汁性肝硬化误诊原因的系统分析[J].实用医学杂志, 2012, 28 (11) :1894-1896.
    [8]HU CJ, YANG GX, LI X, et al.Detection of autoimmune liver disease related autoantibody profiles in patients with primary biliary cirrhoses and its clinical significance[J].Chin J Lab Med, 2010, 33 (2) :115-120. (in Chinese) 胡朝军, 杨国香, 李晞, 等.原发性胆汁性肝硬化患者血清自身免疫性肝病相关自身抗体谱的检测及临床意义[J].中华检验医学杂志, 2010, 33 (2) :115-120.
    [9]LUO LL, ZHOU L, ZHANG J, et al.Value of serum autoantibodies in the diagnosis of anti-mitochondrial antibody-negative primary biliary cirrhosis[J].Chin J Dig, 2015, 35 (2) :86-89. (in Chinese) 罗莉丽, 周璐, 张洁, 等.血清自身抗体在诊断抗线粒体抗体阴性的原发性胆汁性肝硬化中的价值[J].中华消化杂志, 2015, 35 (2) :86-89.
    [10]NORMAN GL, YANG CY, OSTENDORFF HP, et al.Anti-kelchlike 12 and anti-hexokinase 1:Novel autoantibodies in primary biliary cirrhosis[J].Liver Int, 2015, 35 (2) :642-651.
    [11]ZHAO SX, ZHANG YG, ZHOU GD, et al.Clinicopathological features of early-and late-stage primary biliary cirrhosis:Acomparative study[J].Chin J Hepatol, 2016, 24 (6) :412-416. (in Chinese) 赵素贤, 张玉果, 周光德, 等.原发性胆汁性肝硬化早晚期临床病理学对比研究[J].中华肝脏病杂志, 2016, 24 (6) :412-416.
    [12]MURATORI P, MURATORI L, FERRARI R, et al.Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis[J].Am J Gastroenterol, 2003, 98 (2) :431-437.
    [13]CHO YJ, HAN DS, KIM TY, et al.Negative conversion of antimitochondrial antibody in primary biliary cirrhosis:A case of autoimmune cholangitis[J].J Korean Med Sci, 1999, 14 (1) :102-106.
    [14]MASUDA J, OMAGARI K, MATSUO I, et al.Changes in titers of antimitochondrial and antinuclear antibodies during the course of primary biliary cirrhosis[J].J Gastroenterol Hepatol, 2001, 16 (2) :239-243.
    [15]National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association:Fatty Liver Expert Committee, Chinese Medical Doctor Association.Guidelines of prevention and treatment for nonalcoholic fatty liver disease:A 2018 update[J].J Clin Hepatol, 2018, 34 (5) :947-957. (in Chinese) 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会.非酒精性脂肪性肝病防治指南 (2018年更新版) [J].临床肝胆病杂志, 2018, 34 (5) :947-957.
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  • 出版日期:  2019-01-20
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