慢性肝病女性患者绝经后雌激素抗肝纤维化的作用机制

徐文倩; 吴瑶麒; 张近远; 杨天闯; 李合国; 郭敏

doi:10.3969/j.issn.1001-5256.2021.10.035

慢性肝病女性患者绝经后雌激素抗肝纤维化的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.10.035

1.
河南中医药大学第一临床医学院, 郑州 450000
2.
河南中医药大学第一附属医院脾胃肝胆科, 郑州 450000

基金项目:

国家自然科学基金 (81904161)

详细信息

通信作者:
郭敏，hbguomin@sina.com

中图分类号: R575.2
计量
- 文章访问数: 518
- HTML全文浏览量: 160
- PDF下载量: 36
- 被引次数: 0
出版历程
- 收稿日期: 2021-03-11
- 录用日期: 2021-04-22
- 出版日期: 2021-10-20

Mechanism of estrogen against liver fibrosis in postmenopausal women with chronic liver disease

1.
The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (81904161)

摘要

摘要: 女性绝经后机体代谢水平紊乱，患有慢性肝病的女性进展为肝纤维化的风险增加，且风险高于同龄男性患者。这可能与女性绝经后卵巢功能衰退、体内雌激素水平下降有关。主要从雌激素与氧化应激、肝星状细胞的活化、细胞外基质的堆积、免疫调节的关系等方面归纳了患有慢性肝病的女性患者进展为肝纤维化的分子机制研究进展。从而提出给予围绝经期和绝经初期女性患者补充适量的雌激素可以降低肝纤维化的风险，延缓甚至逆转肝纤维化的进程，从而改善老年女性患者的生存质量、延长生存时间。
- 肝硬化 /
- 雌激素类 /
- 绝经期 /
- 女性
Abstract: Metabolic disorders are observed in women after menopause, and the postmenopausal women suffering from chronic liver diseases have an increased risk of progression to liver fibrosis, with a higher risk than male patients of the same age, which may be associated with the decline of ovarian function and the reduction of estrogen level after menopause. This article summarizes the research advances in the molecular mechanism of progression to liver fibrosis from the aspects of estrogen and oxidative stress, activation of hepatic stellate cells, accumulation of extracellular matrix, and immune regulation. It is pointed out supplementation with an appropriate amount of estrogen in the perimenopausal period and the early menopausal period can reduce the risk of liver fibrosis and delay or even reverse the process of liver fibrosis, thereby improving quality of life and prolonging survival time in elderly female patients.
- Liver Cirrhosis /
- Estrogens /
- Menopause /
- Femininity

HTML全文

图 1 雌激素在肝纤维化中的作用机制

注: E2，雌激素受体; ERα, α型雌二醇; ERβ, β型雌二醇; MERs，雌激素受体; GPERs, G蛋白偶联受体; UCP-2, 解偶联蛋白2;ATP，三磷酸腺苷; SOD，超氧化物歧化酶; TCAcycle，三羧酸循环。

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