肠道菌群及其代谢物在胆囊胆固醇结石形成中的作用机制

赵瀚东; 高鹏; 詹丽

doi:10.3969/j.issn.1001-5256.2022.04.042

肠道菌群及其代谢物在胆囊胆固醇结石形成中的作用机制

DOI: 10.3969/j.issn.1001-5256.2022.04.042

赵瀚东¹,
高鹏^2a,
詹丽^2b, ,

1.
甘肃中医药大学第一临床医学院(甘肃省人民医院)，兰州 730000
2a.
甘肃省人民医院普外科, 兰州 730000
2b.
甘肃省人民医院消化科，兰州 730000

基金项目:

国家自然科学基金 (81660398)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：赵瀚东负责文献检索分析，撰写论文；高鹏参与修改论文；詹丽负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
詹丽，zhanlilanzhou@163.com

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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-18
- 录用日期: 2021-09-20
- 出版日期: 2022-04-20

The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones

Handong ZHAO¹,
Peng GAO^2a,
Li ZHAN^{2b
, ,}

1.
The First Clinical Medical College of Gansu University of Chinese Medicine & Gansu Provincial Hospital, Lanzhou 730000, China
2a.
Department of General Surgery, Gansu Provincial People's Hospital, Lanzhou 730000, China
2b.
Department of Gastroenterology, Gansu Provincial People's Hospital, Lanzhou 730000, China

Research funding:

National Natural Science Foundation of China (81660398)

More Information

Corresponding author: ZHAN Li, zhanlilanzhou@163.com

摘要

摘要: 胆囊结石是一种常见的多因素参与的消化系统疾病，80%以上为胆固醇结石，其发病率逐年增加。近年来研究发现肠道菌群参与胆囊胆固醇结石的发生发展。从肠道菌群及其代谢物对胆汁酸调控方面，阐述了肠道菌群及其代谢物在胆囊胆固醇结石发展中的作用，指出未来针对肠道菌群及其代谢产物的干预策略可能是预防和治疗胆囊胆固醇结石的新靶点。
- 胃肠道微生物组 /
- 胆结石 /
- 肠肝循环 /
- 胆汁酸
Abstract: Gallstone is a common digestive system disease involving multiple factors, more than 80% of which are cholesterol gallstones, and its incidence rate is increasing year by year. Recent studies have shown that intestinal flora is involved in the development and progression of cholesterol gallstones. This article elaborates on the role of intestinal flora and its metabolites in the progression of cholesterol gallstones from the aspect of regulation of bile acids by intestinal flora and its metabolites, and it is pointed out that intervention strategies for intestinal flora and its metabolites may be a new target for the prevention and treatment of cholesterol gallstones in the future.
- Gastrointestinal Microbiome /
- Cholelithiasis /
- Enterohepatic Circulation /
- Bile Acid

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参考文献(37)

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