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脑乳酸水平与肝性脑病的关系
DOI: 10.3969/j.issn.1001-5256.2023.07.031
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：刘玉琴负责选题，收集分析资料，撰写文章；陈密、唐兰燕、周丽智、黄鑫参与收集资料，修改论文；张磐拟定写作方向和思路，指导文章撰写，提供修改意见并最终定稿。
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摘要: 肝性脑病(HE)是肝硬化患者常见的并发症，也是肝硬化患者死亡的独立危险因素。脑乳酸水平与HE的进展及严重程度相关，对于脑乳酸水平的研究有助于进一步解释HE的发病机制。本文通过总结脑乳酸代谢过程、脑乳酸水平与HE的关系、HE潜在治疗靶点，为临床医生进一步系统地评估HE患者的病情进展、治疗效果及预后情况提供一定的参考依据，旨在减轻患者医药负担，改善HE患者预后。Abstract: Hepatic encephalopathy (HE) is a common complication and an independent risk factor for death in patients with liver cirrhosis. Brain lactate level is associated with the progression and severity of HE, and research on brain lactate level may help to further explain the pathogenesis of HE. This article summarizes the metabolic process of brain lactate, the association between brain lactate level and HE, and the potential therapeutic targets for HE and provides a reference for clinicians to further systematically evaluate the progression, treatment outcome, and prognosis of patients with HE, in order to reduce the medical burden of patients and improve the prognosis of patients with HE.
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Key words:
- Hepatic Encephalopathy /
- Lactic Acid /
- Blood-Brain Barrier /
- Brain Edema
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