原发免疫性血小板减少症合并HBV感染的研究现状

黄梦贞; 何阳阳; 王诗轩

doi:10.3969/j.issn.1001-5256.2023.09.023

原发免疫性血小板减少症合并HBV感染的研究现状

DOI: 10.3969/j.issn.1001-5256.2023.09.023

1.
赣江新区人民医院血液科，南昌 330029
2.
南昌大学第二附属医院输血科，南昌 330006
3.
南昌大学第一附属医院血液病中心，江西省血液病临床医学研究中心，南昌 330006

基金项目:

国家自然科学基金 (82060030)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：黄梦贞负责文献查找、阅读及文章撰写；何阳阳对研究思路有贡献作用；王诗轩负责文章选题及修改。

详细信息

通信作者:
王诗轩， xiare_2009@163.com （ORCID： 0000－0003－4254－878X）

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- 被引次数: 0
出版历程
- 收稿日期: 2022-12-13
- 录用日期: 2023-01-15
- 出版日期: 2023-09-19

Current research status of primary immune thrombocytopenia with hepatitis B virus infection

1.
Department of Hematology，Ganjiang New Area People’s Hospital，Nanchang 330029，China
2.
Department of Blood Transfusion，The Second Affiliated Hospital of Nanchang University，Nanchang 330006，China
3.
Center of Hematology，The First Affiliated Hospital of Nanchang University，Institute of Hematology，Academy of Clinical Medicine of Jiangxi Province，Nanchang 330006，China

Research funding:

National Natural Science Foundation of China (82060030)

More Information

Corresponding author: WANG Shixuan， xiare_2009@163.com （ORCID： 0000－0003－4254－878X）

摘要

摘要: 原发免疫性血小板减少症（ITP）是一种以血小板破坏增加和生成障碍为特征的自身免疫性疾病。我国是HBV感染的高发区，临床上常发现ITP患者合并HBV感染，HBV感染不仅可以直接抑制血小板生成及加速血小板破坏，同时，还可以通过调节细胞免疫、体液免疫、固有免疫对ITP的发生、发展、临床特征及治疗产生一定的影响，且免疫抑制治疗可能使HBV再激活，使疾病复杂化。本文主要综述ITP合并HBV感染的免疫学特点、预后及治疗进展。
- 紫癜，血小板减少性，特发性 /
- 乙型肝炎病毒 /
- 治疗学 /
- 预后
Abstract: Primary immune thrombocytopenia （ITP） is an autoimmune disease characterized by increased platelet destruction and impaired production. There is a high incidence rate of hepatitis B virus （HBV） infection in China， and it is often observed in clinical practice that ITP patients are often comorbid with HBV infection. HBV infection can not only directly inhibit platelet production and accelerate platelet destruction， but also affect the development， progression， clinical features， and treatment of ITP by regulating cellular immunity， humoral immunity， and innate immunity， and immunosuppressive therapy may cause HBV reactivation and thus lead to complex disease conditions. This article mainly reviews the immunological characteristics， prognosis， and treatment of ITP with HBV infection.
- Purpura， Thrombocytopenic， Idiopathic /
- Hepatitis B Virus /
- Therapeutics /
- Prognosis

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参考文献(43)

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