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热休克蛋白90在HBV复制中的作用
DOI: 10.3969/j.issn.1001-5256.2023.10.023
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：花胤负责撰写和修改论文；方海丽、刘守胜负责参与文献的收集和整理；宣世英、张梅、辛永宁负责拟定写作思路，指导撰写文章并最后定稿。
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摘要: HBV传播范围广，慢性感染状态多，治愈率低，提高HBV治愈率有助于改善患者的长期预后状况。热休克蛋白90（Hsp90）是广泛存在于生物体内的一种分子伴侣蛋白。近年来越来越多的研究表明，Hsp90与HBV感染有关，在HBV的复制过程中起重要作用，可与病毒的特定蛋白相互作用促进病毒复制，也可与宿主自身蛋白相互作用来发挥功能。本文就近年来Hsp90在HBV复制中的作用相关研究进展作一综述，以期为以Hsp90为靶点的抗HBV药物研发与HBV防治提供新的理论指导和方向。
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关键词:
- 乙型肝炎病毒 /
- HSP90热休克蛋白质类 /
- 病毒复制
Abstract: Hepatitis B virus （HBV） has the characteristics of wide transmission， a high chronic infection rate， and a low cure rate， and improving the cure rate of HBV may help to improve the long－term prognosis of patients. Heat shock protein 90 （Hsp90） is a chaperone protein widely present in organisms. In recent years， more and more studies have shown that Hsp90 is associated with HBV infection and plays an important role in HBV replication. It can not only interact with specific proteins of the virus to promote its replication， but also interact with the host’s own proteins to perform its function. This article reviews the role of Hsp90 in HBV replication in recent studies， so as to provide new theoretical guidance and directions for the development of new anti－HBV drugs targeting Hsp90 and the prevention and treatment of HBV infection in the future.-
Key words:
- Hepatitis B Virus /
- HSP90 Heat－Shock Proteins /
- Virus Replication
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图 1 HBV复制过程示意图
注： HBV复制过程起始于rcDNA，rcDNA转化为cccDNA，其转录产物RNA再进一步翻译为蛋白质Pol/RT、HBx、HBeAg、HBsAg、HBc。其中pgRNA、HBc和Pol/RT能够与Hsp90相互作用。此外，宿主蛋白Hsp70、活性氧（reactive oxygen species，ROS）和载脂蛋白B mRNA编辑酶催化多肽3G（apolipoprotein B mRNA editing enzyme catalytic polypeptide－like 3G，A3G）也能够与Hsp90相互作用。
Figure 1. Diagram of HBV replication process
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