代谢相关脂肪性肝病与2型糖尿病的关系及共病机制研究进展

陈兆斌; 黄丽媛; 王炳元; 施军平; 张晶

doi:10.3969/j.issn.1001-5256.2023.10.025

代谢相关脂肪性肝病与2型糖尿病的关系及共病机制研究进展

DOI: 10.3969/j.issn.1001-5256.2023.10.025

1.
济宁医学院临床医学院，山东济宁 272000
2.
中国医科大学附属第一医院老年消化内科，沈阳 110000
3.
杭州师范大学附属医院肝病科，杭州 310000
4.
济宁医学院附属医院消化内科，山东济宁 272000

基金项目:

山东省医药卫生科技发展计划项目 (2019WS366);

济宁医学院博士基金 (2017－BS－007);

山东省自然科学基金 (ZR2019PH068)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：陈兆斌负责查阅文献和撰写论文；张晶负责课题设计，修改论文；黄丽媛负责收集及分析文献资料；王炳元拟定写作思路；施军平指导撰写文章并最后定稿。

详细信息

通信作者:
张晶， zhangjing8809@126.com （ORCID： 0000－0003－2502－3156）

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出版历程
- 收稿日期: 2022-12-28
- 出版日期: 2023-10-30

Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

1.
School of Clinical Medicine，Jining Medical University，Jining，Shandong 272000，China
2.
Department of Elderly Gastroenterology，The First Affiliated Hospital of China Medical University，Shenyang 110000，China
3.
Department of Liver Diseases，The Affiliated Hospital of Hangzhou Normal University，Hangzhou 310000，China
4.
Department of Gastroenterology，Affiliated Hospital of Jining Medical University，Jining，Shandong 272000，China

Research funding:

‍Project of Medical and Health Technology Development Program in Shandong Province (2019WS366);

PhD Research Foundation of Jining Medical University (2017－BS－007);

Natural Science Foundation of Shandong Province (ZR2019PH068)

More Information

Corresponding author: ZHANG Jing， zhangjing8809@126.com （ORCID： 0000－0003－2502－3156）

摘要

摘要: 代谢相关脂肪性肝病和2型糖尿病发病率日益增长，二者关系密切，且相互作用、相互影响，但其具体机制目前尚未明确，研究表明二者之间可能通过胰岛素抵抗、炎症、部分肝细胞因子、细胞衰老互相促进，同时可通过部分肝细胞因子相互保护，进一步加强对2型糖尿病和代谢相关脂肪性肝病的关系及共病机制的研究，对两种疾病的临床预防、治疗具有十分重要的意义。
- 2型糖尿病 /
- 代谢相关脂肪性肝病 /
- 胰岛素抵抗 /
- 炎症 /
- 细胞因子类 /
- 细胞衰老
Abstract: There are gradual increases in the incidence rates of metabolic associated fatty liver disease （MAFLD） and type 2 diabetes mellitus （T2DM）， with close relationship and mutual interaction between the two diseases， but the specific mechanism is still unclear. Studies have shown that T2DM and MAFLD may cause aggravation of each other through insulin resistance， inflammation， some hepatocyte factors， and cellular senescence and protect each other through some hepatocyte factors. Further research on the association between T2DM and MAFLD and the mechanism of comorbidity is of great significance for the clinical prevention and treatment of the two diseases.
- Diabetes Mellitus， Type 2 /
- Metabolic Associated Fatty Liver Disease /
- Insulin Resistance /
- Inflammation /
- Cytokines /
- Cellular Senescence

HTML全文

图 1 MAFLD和T2DM的发病机制

Figure 1. Pathogenesis of MAFLD and T2DM

下载: 全尺寸图片幻灯片

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