自噬对肝衰竭的保护作用机制与临床价值

胡洋洋; 张兴; 罗越; 王亚东; 赵彩彦

doi:10.3969/j.issn.1001-5256.2023.10.030

自噬对肝衰竭的保护作用机制与临床价值

DOI: 10.3969/j.issn.1001-5256.2023.10.030

河北医科大学第三医院湘江院区感染肝病科，石家庄 050051

基金项目:

河北省自然科学基金 (H2020206036);

河北省科技厅重点研发计划项目 (21377756D)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：胡洋洋负责查阅文献，撰写文章；张兴、罗越负责校对文章；王亚东负责指导立题及修改；赵彩彦负责审阅文章等。

详细信息

通信作者:
王亚东， wangyadong8060@126.com （ORCID： 0000－0003－0140－0674）

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出版历程
- 收稿日期: 2023-02-08
- 出版日期: 2023-10-30

Advances in the protective mechanism and clinical implications of autophagy in liver failure

Department of Infectious Diseases，Xiangjiang Branch of The Third Hospital of Hebei Medical University，Shijiazhuang 050051，China

Research funding:

Natural Science Foundation of Hebei Province (H2020206036);

Key Research and Development Project of Hebei Province (21377756D)

More Information

Corresponding author: WANG Yadong， wangyadong8060@126.com （ORCID： 0000－0003－0140－0674）

摘要

摘要: 肝衰竭是一类严重临床肝病症候群，病情危重、病死率高，除肝移植外，缺乏理想的根治性治疗手段。肝衰竭发病机制复杂且尚未完全阐明，多种影响肝细胞坏死与再生平衡的因素参与其中。本文总结了自噬这一维持细胞稳态的关键性途径，指出自噬通过调控NLRP3炎症小体活化、对抗氧化应激、抑制细胞凋亡等多种方式在肝衰竭发病机制中发挥重要保护作用。同时认为外泌体、过氧化物酶体增殖物激活受体α等以自噬为靶点的分子信号通路参与拮抗肝衰竭发生、发展，将成为肝衰竭分子靶向治疗的重要思路和方向。
- 肝功能衰竭 /
- 自噬 /
- 分子靶向治疗
Abstract: ‍Liver failure is a serious clinical syndrome of liver disease with critical condition and high mortality， and besides liver transplantation， there is still a lack of satisfactory radical treatment methods. The pathogenesis of liver failure is complex and remains unclear， involving a variety of factors that affect the balance of hepatocyte necrosis and regeneration. This article summarizes autophagy as the key pathway for maintaining cell homeostasis and points out that autophagy plays an important protective role in the pathogenesis of liver failure by regulating NLRP3 inflammasome activation， reducing oxidative stress， and inhibiting cell apoptosis. Meanwhile， it is believed that the molecular signaling pathways targeting autophagy， such as exosomes and peroxisome proliferator－activated receptor α， participate in antagonizing the development and progression of liver failure and will become important ideas and directions for molecular targeted therapies for liver failure.
- Liver Failure /
- Autophagy /
- Molecular Targeted Therapy

HTML全文

图 1 自噬在肝衰竭中的保护作用机制

注： ARE，抗氧化反应元件；ASC，凋亡相关斑点样蛋白；GCLC，谷氨酸－半胱氨酸连接酶催化亚基；GSTM，谷胱甘肽－S－转移酶Mu；HO－1，血红素加氧酶－1；Keap1， Kelch样ECH相关蛋白1；Nrf2，核因子E2相关因子2；PINK1，PTEN诱导性激酶蛋白1；TXNIP，硫氧还蛋白相互作用蛋白；ΔΨm，线粒体膜电位。

Figure 1. The protective mechanism of autophagy in liver failure

下载: 全尺寸图片幻灯片

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