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肠-肝轴：肠道微生物稳态与肝细胞癌
DOI: 10.3969/j.issn.1001-5256.2023.11.029
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：周荃负责拟定写作思路，检索文献，撰写及修改论文；李金强、蔡春琳负责指导，最终定稿。
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摘要: 肠道微生物群在维持肝脏代谢稳态中扮演重要角色，其通过参与胆汁酸代谢影响肝细胞癌的发生发展。“肠-肝轴”在肝脏疾病发病机制中占据举足轻重的地位，通过纠正肠道生态失衡以恢复正常胆汁酸水平，可能是阻止肝细胞癌进展的有效方法之一。本文总结了胆汁酸受体影响肝细胞癌的相关机制以及最新治疗靶点，旨在为早期防治肝癌提供参考依据。Abstract: Intestinal microbiota plays an important role in maintaining liver metabolic homeostasis and affects the development and progression of hepatocellular carcinoma by participating in bile acid metabolism. Gut-liver axis plays an important role in the pathogenesis of liver diseases， and it might be one of the effective methods to prevent the progression of hepatocellular carcinoma by correcting intestinal ecological imbalance to restore normal bile acid level. This article summarizes the mechanism of bile acid receptor affecting hepatocellular carcinoma and the latest therapeutic targets， in order to provide a reference for the early prevention and treatment of hepatocellular carcinoma.
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