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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2013
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Article Contents

Relationship between laboratory parameters and liver pathology in patients with nonalcoholic steatohepatitis

DOI: 10.3969/j.issn.1001-5256.2013.11.010
  • Received Date: 2013-01-31
  • Published Date: 2013-11-20
  • Objective To investigate the relationship between laboratory parameters and pathological features of the liver in patients with nonalcoholic steatohepatitis ( NASH) and to provide some information for the diagnosis and prognosis of NASH. Methods A retrospective analysis was performed on the clinical data of 206 patients with a histological diagnosis of NASH who were admitted to our hospital from May2008 to December 2011. Laboratory parameters such as alanine aminotransferase ( ALT) and aspartate aminotransferase ( AST) and liver pathology were analyzed statistically. The data on varying degrees of steatosis, inflammation, and fibrosis of the liver were analyzed using the independent- samples t test or one- way analysis of variance, and correlations were determined by Spearman analysis. Results There were significant differences in ALT, AST, and lactate dehydrogenase ( LDH) between patient groups with different degrees of steatosis, inflammation, or fibrosis ( P < 0. 05 for all) , significant differences in white blood cell ( WBC) and alanine phosphatase ( ALP) between patients groups with different degrees of steatosis or fibrosis ( P < 0. 05 for all) , and significant differences in mean corpuscular volume ( MCV) , platelet ( PLT) , albumin ( Alb) , cholinesterase ( CHE) , gamma globulin electrophoresis ( γ- EP) , and glucose ( Glu) between patient groups with different degrees of steatosis ( P < 0. 05 for all) . Correlations existed between the degrees of steatosis and inflammation, between the degrees of steatosis and fibrosis, and between the degrees of inflammation and fibrosis ( r = 0. 261, P < 0. 05; r = 0. 561, P < 0. 05; r =0. 353, P < 0. 05) . Conclusion ALT, AST, and LDH are significantly correlated with the degrees of steatosis, inflammation, and fibrosis, WBC and ALP are significantly correlated with the degrees of steatosis and fibrosis, and MCV, PLT, Alb, CHE, γ- EP, and Glu are significantly correlated with the degree of steatosis.

     

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