中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2014
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Article Contents

Sorafenib-related adverse events in treatment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2014.03.021
  • Published Date: 2014-03-20
  • Sorafenib can significantly improve the prognosis of patients with advanced hepatocellular carcinoma ( HCC) , and it acts as an antagonist of the anti- angiogenic targets of vascular endothelial growth factor receptors and platelet- derived growth factor receptors and an inhibitor of the Raf / MEK / ERK signaling pathway to suppress tumor growth. However, the improvement in patients' quality of life is compromised by frequent sorafenib- related adverse events. The pharmacological mechanism of the small- molecule targeted drug sorafenib in the treatment of HCC is reviewed, and the incidence, characteristics, prevention, and treatment of common sorafenib- related adverse events are summarized. Additionally, the relationship between sorafenib- related adverse events and the antitumor effect of sorafenib is elucidated. It is suggested that clinicians should consider the pros and cons comprehensively when using sorafenib in treating HCC.

     

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