Objective To evaluate the clinical effects of laparoscopic hepatectomy (LH) versus open hepatectomy (OH) in treating liver metastasis of colon cancer. Methods Relevant literature published up to October 2014 was retrieved from databases including Pub Med, Medline, Embase, and Cochrane Library. Extended search was done with reference to the retrieved articles. The quality of selected studies was assessed by the Jadad scale. Meta-analysis was performed using the Cochrane Review Manager software (Version 5. 3. 4) . Results A total of 10 studies involving 786 patients met the inclusion criteria. Meta-analysis showed no significant differences in duration of operation, perioperative mortality, and 5-year overall survival rate between patients undergoing LH and OH (95% CI:-61. 98-23. 68, 0. 08-4. 05, and 0. 60-1. 58, respectively, P > 0. 05 for all) , but there were significant differences in intraoperative blood loss, incidence of postoperative complications, and length of hospital stay (95% CI:-323. 17- (-113. 00) , 0. 38-0. 77, and-5. 01- (-2. 04) , respectively, P < 0. 05) . Conclusion The results of this meta-analysis suggest that LH has comparable efficacy and safety to OH in treating liver metastasis of colon cancer and LH has its own advantage.
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