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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2014
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Article Contents

Diagnosis and treatment of acute kidney injury in patients with cirrhosis

DOI: 10.3969/j.issn.1001-5256.2014.12.030
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  • Received Date: 2014-04-28
  • Published Date: 2014-12-20
  • Acute kidney injury is a common complication in patients with cirrhosis. It is characterized by a sudden drop in glomerular filtration rate, retention of metabolic waste products, water-electrolyte imbalance, and acid-base disturbance. It markedly increases mortality in cirrhotic patients. Therefore, early diagnosis and treatment of acute kidney injury are essential to reduce mortality and improve prognosis.The development of the diagnostic criteria for acute kidney injury, the clinical application of new biomarkers of renal function such as cystatin C, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin, and the management of acute kidney injury in cirrhotic patients are reviewed. Although creatinine test and monitoring of urinary output have their disadvantages, they remain the main diagnostic criteria for acute kidney injury. Development of new biomarkers for clinical use and elucidation of the underlying mechanisms of acute kidney injury have become a hotspot of basic and clinical research.

     

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