Myosin light chain kinase( MLCK) is a key enzyme involved in intestinal mucosal mechanical barrier and plays an important role in the pathogenesis of nonalcoholic fatty liver disease( NAFLD). This article describes the " two- hit theory" for NAFLD and gut- derived endotoxin which plays a major role in the pathogenesis of NAFLD,the relationship between endotoxin,MLCK,and NAFLD,and the impact of MLCK inhibitor ML- 7 on the intestinal barrier. MLCK inhibitor ML- 7 may hinder and delay the development and progression of NAFLD,providing a novel clinical idea for the early prevention of NAFLD.
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