All tumor necrosis factor( TNF) antagonists are associated with hepatotoxicity and thus induce liver injury,commonly manifested as hepatitis B virus and hepatitis C virus reactivation,acute hepatitis,drug- induced liver disease,cholestasis,serum liver enzyme activity elevation,and even acute liver failure. Hence,the application of TNF antagonists in hepatic disease treatment remains controversial. This review summarizes currently available data on the mechanism and application of TNF antagonists in hepatic disease treatment. Although TNF antagonists have been applied for many years,large randomized controlled trials are still recommended to assess its efficacy and safety and to achieve a consensus.
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