中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 9
Sep.  2016
Turn off MathJax
Article Contents

Disease assessment and prognosis of liver failure

DOI: 10.3969/j.issn.1001-5256.2016.09.008
  • Published Date: 2016-09-20
  • Liver failure has a high fatality rate and greatly threatens human health. Liver transplantation can effectively reduce the fatality rate. However,the problems such as donor shortage and allograft rejection limit the wide application of liver transplantation. An accurate early assessment helps to evaluate patients' condition and optimize therapeutic strategies. At present,commonly used systems for prognostic evaluation include the King's College Hospital,MELD,integrated MELD,Child- Pugh score,CLIF- SOFA,CLIF- C ACLFS,and D- MELD,and each system has its own advantages and disadvantages. Among these systems,the MELD scoring system is the most commonly used one,and the D- MELD scoring system is the most innovative one,which can be used for patients on the waiting list for liver transplantation. This article elaborates on the characteristics and predictive value of each scoring system in clinical practice.

     

  • loading
  • [1] POLSON J,LEE WM.American Association for the Study of Liver D.AASLD position paper:the management of acute liver failure[J].Hepatology,2005,41(5):1179-1197.
    [2]SIMPSON KJ,BATES CM,HENDERSON NC,et al.The utilization of liver transplantation in the management of acute liver failure:comparison between acetaminophen and non-acetaminophen etiologies[J].Liver Transpl,2009,15(6):600-609.
    [3]BAILEY B,ANRE DK,GAUDREAULT P.Fulminant hepatic failure secondary to acetaminophen poisoning:a systematic review and metaanalysis of prognostic criteria determining the need for liver transplantation[J].Crit Care Med,2003,31(1):299-305.
    [4]KUMAR R,SHALIMAR,SHARMA H,et al.Prospective derivation and validation of early dynamic model for predicting outcome in patients with acute liver failure[J].Gut,2012,61(7):1068-1075.
    [5]ASRANI SK,KAMATH PS.Model for end-stage liver disease score and MELD exceptions:15 years later[J].Hepatol Int,2015,9(3):346-354.
    [6]HE WP,HU JH,ZHAO J,et al.Comparison of four prognostic models and a new Logistic regression model to predict short-term prognosis of acute-on-chronic hepatitis B liver failure[J].Chin Med J(Engl),2012,125(13):2272-2278.
    [7]SHI Y,YANG Y,HU Y,et al.Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults[J].Hepatology,2015,62(1):232-242.
    [8]MOREAU R,JALAN R,GINES P,et al.Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis[J].Gastroenterology,2013,144(7):1426-1437.
    [9]ANGELI P,RODRIGUEZ E,PIANO S,et al.Acute kidney injury and acute-on-chronic liver failure classifications in prognosis assessment of patients with acute decompensation of cirrhosis[J].Gut,2015,64(10):1616-1622.
    [10]Mc PHAIL MJ,SHAWCROSS DL,ABLES RD,et al.Increased survival for patients with cirrhosis and organ failure in liver intensive care and validation of the chronic liver failure-sequential organ failure scoring system[J].Clin Gastroenterol Hepatol,2015,13(7):1353-1360.
    [11]JALAN R,SALIBA F,PAVESI M,et al.Development and validation of a prognostic score to predict mortality in patients with acuteon-chronic liver failure[J].J Hepatol,2014,61(5):1038-1047.
    [12]GUSTOT T,FERNANDEZ J,GARCIA E,et al.Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis[J].Hepatology,2015,62(1):243-252.
    [13]REDDY SS,CIVAN JM.From child-pugh to model for end-stage liver disease:deciding who needs a liver transplant[J].Med Clin North Am,2016,100(3):449-464.
    [14]WU FL,SHI KQ,CHEN YP,et al.Scoring systems predict the prognosis of acute-on-chronic hepatitis B liver failure:an evidence-based review[J].Expert Rev Gastroenterol Hepatol,2014,8(6):623-632.
    [15]HONG G,LEE KW,SUH S,et al.The model for end-stage liver disease score-based system predicts short term mortality better than the current Child-Turcotte-Pugh score-based allocation system during waiting for deceased liver transplantation[J].J Korean Med Sci,2013,28(8):1207-1212.
    [16]MARTIN P,DIMARTINI A,FENG S,et al.Evaluation for liver transplantation in adults:2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation[J].Hepatology,2014,59(3):1144-1165.
    [17]LEE WC,CHOU HS,WU TJ,et al.Indicators and outcome of liver transplantation in acute liver decompensation after flares of hepatitis B[J].J Viral Hepat,2011,18(3):193-199.
    [18]CARDENAS A,SOLA E,RODRIGUEZ E,et al.Hyponatremia influences the outcome of patients with acute-on-chronic liver failure:an analysis of the CANONIC study[J].Crit Care,2014,18(6):700.
    [19]KIM WR,BIGGINS SW,KREMERS WK,et al.Hyponatremia and mortality among patients on the liver-transplant waiting list[J].N Engl J Med,2008,359(10):1018-1026.
    [20]HALLDORSON JB,BAKTHAVATSALAM R,FIX O,et al.DMELD,a simple predictor of post liver transplant mortality for optimization of donor/recipient matching[J].Am J Transplant,2009,9(2):318-326.
    [21]AVOLIO AW,AGNES S,CILLO U,et al.http://www.DMELD.com,the Italian survival calculator to optimize donor to recipient matching and to identify the unsustainable matches in liver transplantation[J].Transpl Int,2012,25(3):294-301.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2494) PDF downloads(473) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return