Risk factors for hypertriglyceridemia-induced acute pancreatitis

Objective To investigate the risk factors for hypertriglyceridemia-induced acute pancreatitis, and to provide a reference for clinical prevention and treatment. Methods A total of 42 patients with hypertriglyceridemia-induced acute pancreatitis who were admitted to The People's Hospital of Guang'an from January 2014 to June 2016 were enrolled as study group, and 42 patients with non-hypertriglyceridemia-induced acute pancreatitis ( biliary or alcoholic) were enrolled as control group. The two groups were compared in terms of sex, age, fatty liver, body mass index ( BMI) , type 2 diabetes, hyperlipidemia, family history of hyperlipidemia, serum triglyceride, serum cholesterol, low-density lipoprotein ( LDL) , high-density lipoprotein ( HDL) , whole blood low-shear viscosity, and D-dimer concentration at the time when they visited the hospital. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. A multivariate non-conditional logistic regression analysis was performed for the statistically significant variables identified in the univariate analysis. Results The univariate analysis showed that there were significant differences between the two groups in sex, fatty liver, BMI, type 2 diabetes, hyperlipidemia, family history of hyperlipidemia, serum triglyceride level, whole blood low-shear viscosity, whole blood high-shear viscosity, and D-dimer concentration ( all P < 0. 05) . The multivariate non-conditional logistic regression analysis showed that type 2 diabetes ( odds ratio [OR]= 2. 206, 95% confidence interval[95% CI]: 1. 125-4. 263, P = 0. 024) , serum triglyceride level ( OR = 5. 253, 95% CI: 2. 502-9. 568, P = 0. 001) , BMI ( OR =3. 812, 95% CI: 1. 896-7. 529, P = 0. 011) , fatty liver ( OR = 4. 255, 95% CI: 2. 185-8. 236, P = 0. 009) , and D-dimer concentration ( OR = 6. 258, 95% CI: 3. 526-11. 653, P = 0. 006) were independent risk factors for hypertriglyceridemia-induced acute pancreatitis. Conclusion It is of great clinical significance to provide intervention for risk factors for hypertriglyceridemia-induced acute pancreatitis and minimize its incidence rate.