Objective To investigate the association between acute ischemic cerebral infarction (AICI) and nonalcoholic fatty liver disease (NAFLD) in Uygur patients in Urumqi, China and possible risk factors. Methods A retrospective analysis was performed for the clinical data of 294 Uygur patients with AICI who were admitted to The Second Affiliated Hospital of Xinjiang Medical University from September2011 to July 2017, and according to the diagnosis based on abdominal ultrasound, these patients were divided into case group with 110 patients (AICI complicated by NAFLD) and control group with 184 patients (without NAFLD) . The two groups were observed in terms of general information, biochemical parameters, and intima-media thickness (IMT) of the common carotid artery. The AICI patients were divided into ≤30 years group, 31-45 years group, 46-60 years group, 61-75 years group, and ≥60 years group according to age, and the incidence rate of NAFLD was compared between these groups. The t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, and a multivariate logistic regression analysis was performed.Results Compared with the control group, the case group had significantly higher age, body mass index, waist-hip ratio, Hb A1 c, fasting blood glucose, uric acid, alanine aminotransferase (ALT) , gamma-glutamyl transpeptidase, triglyceride (TG) , total cholesterol, and low-density lipoprotein cholesterol (LDL-C) and a significantly lower aspartate aminotransferase level (t = 9. 814, 5. 569, 8. 139, 3. 592, 3. 514, 15. 703, 15. 113, 8. 092, 10. 834, 7. 719, 11. 481, and 7. 561, all P < 0. 05) . The case group had a significantly higher proportion of the patients with a smoking history than the control group (χ2= 14. 060, P < 0. 05) . The logistic regression analysis showed that the increases in age (odds ratio [OR]= 1. 301, 95% confidence interval [CI]: 1. 065-1. 589, P < 0. 05) and serum levels of ALT (OR =1. 383, 95% CI: 1. 059-1. 805, P < 0. 05) , TG (OR = 1. 335, 95% CI: 1. 091-1. 634, P < 0. 05) , and LDL-C (OR = 1. 358, 95%CI: 1. 125-1. 639, P < 0. 05) and a smoking history (OR = 1. 423, 95% CI: 1. 105-1. 833, P < 0. 05) were closely associated with NAFLD in AICI patients. The incidence rate of NAFLD in AICI patients increased with age, and there was a significant difference between different age groups (χ2= 13. 558, P = 0. 009) ; the 61-75 years group and the > 76 years group had an incidence rate of NAFLD of44. 09% and 51. 35%, respectively, which were significantly higher than that in the other three groups (P < 0. 05) . Conclusion Increases in age and serum levels of ALT, TG, and LDL-C and a smoking history are independent risk factors for NAFLD in patients with AICI, and AICI patients aged over 60 years have a high incidence rate of NAFLD.
DownLoad: