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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 7
Jul.  2018
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Article Contents

Association of regulatory T cells, T helper 17 cells, and change in their balance with autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2018.07.045
  • Received Date: 2018-01-08
  • Published Date: 2018-07-20
  • Autoimmune hepatitis ( AIH) is a chronic liver inflammatory disease, and its etiology and pathogenesis remain unclear. In recent years, abnormal immune regulation mechanism has become a research hotspot. Regulatory T ( Treg) cells and Th17 cells are two subsets of CD4+T cells and there are significant differences in function and differentiation between them. Treg/Th17 balance plays an important role in maintaining the stability of human immune system, and Treg/Th17 imbalance will cause abnormal immune response and then lead to autoimmune diseases. In-depth studies on the role of Treg and Th17 cells in the pathogenesis of AIH may provide new strategies for immunotherapy for this disease. This article reviews the change in Treg/Th17 balance in autoimmune hepatitis.

     

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