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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2018
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Article Contents

Biological functions of apoptosis stimulating protein of p53 2 and its role in liver diseases

DOI: 10.3969/j.issn.1001-5256.2018.11.039
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  • Published Date: 2018-11-20
  • Apoptosis stimulating protein of p53 2 ( ASPP2) is a member of the apoptosis stimulating proteins of p53 and can specifically bind to the core region of p53 protein and enhance the ability of p53 to promote transcription of apoptotic genes. At present, it is believed that ASPP2 plays an important role in regulating cell apoptosis, autophagy, proliferation and affecting the progression of inflammation and tumors.This article summarizes the main biological functions of ASPP2 and the research advances in the role of ASPP2 in hepatocellular carcinoma, hepatitis C, and nonalcoholic fatty liver disease. Studies have shown that ASPP2 can regulate cell apoptosis and may be a potential therapeutic target for a variety of diseases.

     

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  • [1] SULLIVAN A, LU X. ASPP:a new family of oncogenes and tumour suppressor genes[J]. Br J Cancer, 2007, 96 (2) :196-200.
    [2] WANG Z, LIU Y, TAKAHASHI M, et al. N terminus of ASPP2binds to ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence[J]. Proc Natl Acad Sci U S A, 2013, 110 (1) :312-317.
    [3] IWABUCHI K, BARTEL PL, LI B, et al. Two cellular proteins that bind towild-type but not mutant p53[J]. Proc Natl Acad Sci U S A, 1994, 91 (13) :6098-6102.
    [4] MOSAVI LK, CAMMETT TJ, DESROSIERS DC, et al. The ankyrin repeat as molecular architecture for protein recognition[J]. Protein Sci, 2004, 13 (6) :1435-1448.
    [5] SAMUELS-LEV Y, O'CONNOR DJ, BERGAMASCHI D, et al.ASPP proteins specifically stimulate the apoptotic function of p53[J]. Mol Cell, 2001, 8 (4) :781-794.
    [6] TIDOW H, ANDREEVA A, RUTHERFORD TJ, et al. Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveal saubiquitin-likefold[J]. J Mol Biol, 2007, 371 (4) :948-958.
    [7] LIU K, YIN JM, DING W, et al. ASPP2 enhances the effect of DRAM induced autophagy on promoting apoptosis in Hep G2 cells[J]. Chin J Biochem Mol Biol, 2012, 28 (11) :1011-1017. (in Chinese) 刘凯, 殷继明, 丁渭, 等. ASPP2过表达可增强DRAM介导的自噬对Hep G2细胞的促调亡作用[J].中国生物化学与分子生物学报, 2012, 28 (11) :1011-1017.
    [8] LIU K, WANG AN, JIANG T, et al. ASPP2 promotes p53-independent autophagy-induced apoptosis in Hep3B cells[J]. Chin J Biochem Mol Biol, 2013, 29 (7) :636-642. (in Chinese) 刘凯, 王安娜, 姜涛, 等. ASPP2以p53非依赖形式促进自噬引起Hep3B细胞凋亡[J].中国生物化学与分子生物学报, 2013, 29 (7) :636-642.
    [9] WANG Z, LIU Y, TAKAHASHI M, et al. N terminus of ASPP2binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence[J]. Proc Natl Acad Sci U S A, 2013, 110 (1) :312-317.
    [10] BERGAMASCHI D, SAMUELS Y, JIN B, et al. ASPP1 and ASPP2:Common activators of p53 family members[J]. Mol Cell Biol, 2004, 24 (3) :1341-1350.
    [11] LIU K, ZENG XW, JI XM, et al. Progresses in study on the apoptosis stimulating proteins of p53 family regulate autophagy[J]. J Clin Pathol Res, 2016, 36 (6) :859-863. (in Chinese) 刘宽, 曾现伟, 吉训明, 等. p53凋亡刺激蛋白家族对自噬调控作用的研究进展[J].临床与病理杂志, 2016, 36 (6) :859-863.
    [12] WANG Y, WANG XD, LAPI E, et al. Autophagic activity dictates the cellular response to oncogenic RAS[J]. Proc Natl Acad Sci USA, 2012, 109 (33) :13325-13330.
    [13] SHI Y, HAN Y, XIE F, et al. ASPP2 enhances oxaliplatin (LOHP) -induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy[J]. J Cell Mol Med, 2015, 19 (3) :535-543.
    [14] SONG B, BIAN Q, ZHANG YJ, et al. Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation[J]. Mol Cancer, 2015, 14 (1) :177.
    [15] XIE F, JIA L, LIN M, et al. ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease[J]. J Cell Mol Med, 2015, 19 (1) :155-164.
    [16] LIU K, SHI Y, GUO X, et al. CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2[J]. Cell Death Dis, 2014, 5:e1323.
    [17] TURNQUIST C, WANG Y, SEVERSON DT, et al. STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression[J]. Proc Natl Acad Sci USA, 2014, 111 (27) :9834-9839.
    [18] SAMUELS-LEVY, O'CONNORDJ, BERGAMASCHID, et al.ASPP proteins specifically stimulate the apoptotic function of p53[J]. Mol Cell, 2001, 8 (4) :781-794.
    [19] LIU ZJ, ZHANG Y, ZHANG XB, et al. Abnormal m RNA expression of ASPP members in leukemia cell lines[J]. Leukemia, 2004, 18 (4) :880.
    [20] LOSSOSIS, NATKUNAMY, LEVYR, et al. Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma:Correlation with clinical outcome[J]. Leuk Lymphoma, 2002, 43 (12) :2309-2317.
    [21] ZHU YP, WANG DJ, HE YH. Expression of Aspp1 and ASPP2protein in human brain glioma and its relationship with apoptosis[J]. Guangdong Med J, 2012, 33 (13) :1964-1968. (in Chinese) 朱泳鹏, 王东军, 何友虎.人脑胶质瘤中Aspp1和ASPP2蛋白的表达及其与细胞凋亡的相关性[J].广东医学, 2012, 33 (13) :1964-1968.
    [22] VIVES V, SLEE E A, LU X. ASPP2:A gene that controls life and death in vivo[J]. Cell Cycle, 2006, 5 (19) :2187-2190.
    [23] CHEN Y, LIU W, NAUMOVSKI L, et al. ASPP2 inhibits APPBP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis[J]. J Neurochem, 2003, 85:801-809.
    [24] ZHU C, BAO N, CHEN S, et al. Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβpathway[J]. Mol Med Rep, 2017, 16 (4) :4922-4926.
    [25] MA L, CHEN ZM, LI XY, et al. Nucleostemin and ASPP2 expression is correlated with pituitary adenoma proliferation[J]. Oncol Letters, 2013, 6 (5) :1313-1318.
    [26] ZHENG KM, WU G, QIN XM, et al. Effects of XAV393 on proliferation and glycolysis of hepatocellular carcinoma cells[J]. Mod Oncol, 2016, 24 (13) :2023-2026. (in Chinese) 郑昆明, 吴刚, 秦晓明, 等. XAV939对肝癌细胞增殖及糖酵解的影响[J].现代肿瘤医学, 2016, 24 (13) :2023-2026.
    [27] CALVISI DF, LADU S, GORDEN A, et al. Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma[J]. J Clin Invest, 2007, 117:2713-2722.
    [28] ZHAO J, WU G, BU F, et al. Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-richregion-containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma[J]. Hepatology, 2010, 51 (1) :142.
    [29] WU GB. The experimental research on the m RNA expression Aspp1, ASPP2 and the CpG island methylation of their promoters in hepatocellular carcinoma[D]. Nanning:Guangxi Med Univ, 2008. (in Chinese) 邬国斌.肝细胞癌中Aspp1、ASPP2基因表达及其启动子区CpG岛甲基化的实验研究[D].南宁:广西医科大学, 2008.
    [30] CHEN R, WANG H, LIANG B, et al. Downregulation of ASPP2improves hepatocellular carcinoma cells survival via promoting BECN1-dependent autophagy initiation[J]. Cell Death Dis, 2016, 7 (12) :e2512.
    [31] National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association; Fatty Liver Expert Committee, Chinese Medical Doctor Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease:A 2018 update[J]. J Clin Hepatol, 2018, 34 (5) :947-957. (in Chinese) 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会.非酒精性脂肪性肝病防治指南 (2018年更新版) [J].临床肝胆病杂志, 2018, 34 (5) :947-957.
    [32] SINGH R, KAUSHIK S, WANG Y, et al. Autophagy regulates lipid metabolism[J]. Nature, 2009, 458:1131-1135.
    [33] XIE F, JIA L, LIN M, et al. ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease[J]. J Cell Mol Med, 2015, 19 (1) :155-164.
    [34] WANG Y, WANG XD, LAPI E, et al. Autophagic activity dictates the cellular response to oncogenic RAS[J]. Proc Natl Acad Sci USA, 2012, 109:13325-13330.
    [35] ZHANG L, CARDINAL JS, BAHAR R, et al. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide[J]. Mol Med, 2012, 18:201-208.
    [36] BRISTOL ML, DI X, BECKMAN MJ, et al. Dual functions of autophagy in the response of breast tumor cells to radiation:Cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3[J]. Autophagy, 2012, 8:739-753.
    [37] XING X, LI LP, WANG L, et al. Changes and functions of hepatic macrophages in viral hepatitis C infection[J]. Chin J Clin Pharmacol Ther, 2017, 22 (9) :1072-1076. (in Chinese) 邢欣, 李丽萍, 王鹿, 等.丙型病毒性肝炎中肝脏巨噬细胞的变化及作用[J].中国临床药理学与治疗学, 2017, 22 (9) :1072-1076.
    [38] ZHANG LL, FENG GH. Advances in hepatitis C virus core protein[J]. World Chin J Dig, 2008, 16 (18) :2019-2024. (in Chinese) 张莉莉, 冯国和.丙型肝炎病毒核心蛋白作用研究进展[J].世界华人消化杂志, 2008, 16 (18) :2019-2024.
    [39] CAO Y, HAMADA T, MATSUI T, et al. Hepatitis C virus core protein interacts with p53-bindingprotein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis[J]. Biochem Biophys Res Commun, 2004, 315 (4) :788-795.
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