中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 2
Feb.  2020
Turn off MathJax
Article Contents

Research advances in intraductal papillary neoplasm of the bile duct

DOI: 10.3969/j.issn.1001-5256.2020.02.054
Research funding:

 

  • Received Date: 2019-09-17
  • Published Date: 2020-02-20
  • Intraductal papillary neoplasm of the bile duct( IPNB) is a rare type of bile duct tumors with different classification criteria and has a better prognosis than cholangiocarcinoma. Clinicians lack the awareness of this disease due to its low incidence rate. This article reviews recent research advances in the etiology and pathogenesis,pathological characteristics,clinical features,differential diagnosis,treatment and prognosis of IPNB,in order to improve the clinical diagnosis and treatment of IPNB.

     

  • loading
  • [1] ZEN Y,SASAKI M,FUJII T,et al. Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct-an immunohistochemical study of 110 cases of hepatolithiasis[J]. J Hepatol,2006,44(2):350-358.
    [2] YING S,YING M,LIANG W,et al. Morphological classification of intraductal papillary neoplasm of the bile duct[J]. Eur Radiol,2018,28(4):1568-1578.
    [3] OHTSUKA M,KIMURA F,SHIMIZU H,et al. Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion[J]. Am J Surg Pathol,2011,35(4):512-521.
    [4] NAKANUMA Y,JANG KT,FUKUSHIMA N,et al. A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage[J]. J Hepatobiliary Pancreat Sci,2018,25(3):181-187.
    [5] NAKANUMA Y,KAKUDA Y,UESAKA K,et al. Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm[J]. Hum Pathol,2016,51:103-113.
    [6] ROCHA FG,LEE H,KATABI N,et al. Intraductal papillary neoplasm of the bile duct:A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas?[J]. Hepatology,2012,56(4):1352-1360.
    [7] YANG J,WANG W,YAN L. The clinicopathological features of intraductal papillary neoplasms of the bile duct in a Chinese population[J]. Dig Liver Dis,2012,44(3):251-256.
    [8] KUBOTA K,NAKANUMA Y,KONDO F,et al. Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver:A multi-institutional study by the Japan Biliary Association[J]. J Hepatobiliary Pancreat Sci,2014,21(3):176-185.
    [9] SCHLITTER AM,BORN D,BETTSTETTER M,et al. Intraductal papillary neoplasms of the bile duct:Stepwise progression to carcinoma involves common molecular pathways[J]. Mod Pathol,2014,27(1):73-86.
    [10] FUKUMURA Y,NAKANUMA Y,KAKUDA Y,et al. Clinicopathological features of intraductal papillary neoplasms of the bile duct:A comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes[J]. Virchows Arch,2017,471(1):65-76.
    [11] LUVIRA V,PUGKHEM A,BHUDHISAWASDI V,et al. Longterm outcome of surgical resection for intraductal papillary neoplasm of the bile duct[J]. J Gastroenterol Hepatol,2017,32(2):527-533.
    [12] TAN Y,MILIKOWSKI C,TORIBIO Y,et al. Intraductal papillary neoplasm of the bile ducts:A case report and literature review[J]. World J Gastroenterol,2015,21(43):12498-12504.
    [13] CHATTERJEE A,LOPES VENDRAMI C,NIKOLAIDIS P,et al.Uncommon intraluminal tumors of the gallbladder and biliary tract:Spectrum of imaging appearances[J]. Radiographics,2019,39(2):388-412.
    [14] XIAN ZH,QIN C,CONG WM. KRAS mutation and immunohistochemical profile in intraductal papillary neoplasm of the intrahepatic bile ducts[J]. Pathol Res Pract,2018,214(1):105-111.
    [15] FUJIKURA K,AKITA M,AJIKI T,et al. Recurrent mutations in APC and CTNNB1 and activated Wnt/β-catenin signaling in intraductal papillary neoplasms of the bile duct:A whole exome sequencing study[J]. Am J Surg Pathol,2018,42(12):1674-1685.
    [16] TANAKA M,SHIBAHARA J,ISHIKAWA S,et al. EVI1 expression is associated with aggressive behavior in intrahepatic cholangiocarcinoma[J]. Virchows Arch,2019,474(1):39-46.
    [17] WAN XS,XU YY,QIAN JY,et al. Intraductal papillary neoplasm of the bile duct[J]. World J Gastroenterol,2013,19(46):8595-8604.
    [18] OHTSUKA M,SHIMIZU H,KATO A,et al. Intraductal papillary neoplasms of the bile duct[J]. Int J Hepatol,2014,2014:459091.
    [19] WANG X,CAI YQ,CHEN YH,et al. Biliary tract intraductal papillary mucinous neoplasm:Report of 19 cases[J]. World J Gastroenterol,2015,21(14):4261-4267.
    [20] YING SH,ZHAO YL,TENG XD,et al. Imaging findings and morphology classification of intraductal papillary mucinous neoplasm of the bile duct[J]. Chin J Radiol,2015,49(1):42-46.(in Chinese)应世红,赵艺蕾,滕晓东,等.胆管导管内乳头状黏液性肿瘤的影像表现和形态分型[J].中华放射学杂志,2015,49(1):42-46.
    [21] KLOEK JJ,van der GAAG NA,ERDOGAN D,et al. A comparative study of intraductal papillary neoplasia of the biliary tract and pancreas[J]. Hum Pathol,2011,42(6):824-832.
    [22] GORDON-WEEKS AN,JONES K,HARRISS E,et al. Systematic review and meta-analysis of current experience in treating IPNB:Clinical and pathological correlates[J]. Ann Surg,2016,263(4):656-663.
    [23] KIM KM,LEE JK,SHIN JU,et al. Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype[J]. Am J Gastroenterol,2012,107(1):118-125.
    [24] LI LT,WU B,WANG SQ,et al. Intrahepatic biliary papillomatosis with local canceration:A case report[J]. J Clin Hepatol,2018,34(8):1760-1762.(in Chinese)李良涛,武波,王守乾,等.肝内胆管乳头状瘤伴局部癌变1例报告[J].临床肝胆病杂志,2018,34(8):1760-1762.
    [25] JUNG G,PARK KM,LEE SS,et al. Long-term clinical outcome of the surgically resected intraductal papillary neoplasm of the bile duct[J]. J Hepatol,2012,57(4):787-793.
    [26] LOU JY,SU W,WEI SM,et al. Clinical features,diagnosis and treatment of intraductal papillary neoplasm of the bile duct[J]. Chin J Surg,2018,56(5):350-354.(in Chinese)楼健颖,粟伟,魏树梅,等.胆管导管内乳头状肿瘤的临床特征及诊治分析[J].中华外科杂志,2018,56(5):350-354.
    [27] XIAO JZ,XIAO Y,LIAO JT,et al. Ultrasonic characteristics of intraductal papillary mucinous neoplasm of the bile duct[J].Chin J Ultrasonogr,2017,26(12):1039-1042.(in Chinese)肖静珍,肖萤,廖锦堂,等.胆管乳头状黏液性肿瘤的超声图像特征[J].中华超声影像学杂志,2017,26(12):1039-1042.
    [28] ZHENG Q,RUAN SM,SHAN QY,et al. Clinicopathological findings and imaging features of intraductal papillary neoplasm of the bile duct:Comparison between contrast-enhanced ultrasound and contrast-enhanced computed tomography[J].Abdom Radiol(NY),2019,44(7):2409-2417.
    [29] LIU LN,XU HX,ZHENG SG,et al. Ultrasound findings of intraductal papillary neoplasm in bile duct and the added value of contrast-enhanced ultrasound[J]. Ultraschall Med,2015,36(6):594-602.
    [30] LIU LN,XU HX,ZHANG YF,et al. Imaging features of intraductal papillary neoplasm of bile duct(IPN-B)on baseline ultrasound and contrast-enhanced ultrasound[J]. Chin J Ultrasonogr,2012,21(11):969-972.(in Chinese)刘琳娜,徐辉雄,张一峰,等.胆管内乳头状肿瘤超声及超声造影表现[J].中华超声影像学杂志,2012,21(11):969-972.
    [31] OGAWA H,ITOH S,NAGASAKA T,et al. CT findings of intraductal papillary neoplasm of the bile duct:Assessment with multiphase contrast-enhanced examination using multi-detector CT[J]. Clin Radiol,2012,67(3):224-231.
    [32] LIU Y,ZHONG X,YAN L,et al. Diagnostic performance of CT and MRI in distinguishing intraductal papillary neoplasm of the bile duct from cholangiocarcinoma with intraductal papillary growth[J]. Eur Radiol,2015,25(7):1967-1974.
    [33] SIRIPONGSAKUN S,SAPTHANAKORN W,MEKRAKSAKIT P,et al. Premalignant lesions of cholangiocarcinoma:Characteristics on ultrasonography and MRI[J]. Abdom Radiol(NY),2019,44(6):2133-2146.
    [34] YOON HJ,KIM YK,JANG KT,et al. Intraductal papillary neoplasm of the bile ducts:Description of MRI and added value of diffusion-weighted MRI[J]. Abdom Imaging,2013,38(5):1082-1090.
    [35] HONG GS,BYUN JH,KIM JH,et al. Thread sign in biliary intraductal papillary mucinous neoplasm:A novel specific finding for MRI[J]. Eur Radiol,2016,26(9):3112-3120.
    [36] LEE S,KIM MJ,KIM S,et al. Intraductal papillary neoplasm of the bile duct:Assessment of invasive carcinoma and long-term outcomes using MRI[J]. J Hepatol,2019,70(4):692-699.
    [37] TSUYUGUCHI T,SAKAI Y,SUGIYAMA H,et al. Endoscopic diagnosis of intraductal papillary mucinous neoplasm of the bile duct[J]. J Hepatobiliary Pancreat Sci,2010,17(3):230-235.
    [38] SUN B,HU B. The role of intraductal ultrasonography in pancreatobiliary diseases[J]. Endosc Ultrasound,2016,5(5):291-299.
    [39] LIU YB,LI M,ZHONG XM,et al. Imaging features of intraductal papillary neoplasm of the bile duct[J]. Chin J Radiol,2014,48(2):128-131.(in Chinese)刘于宝,李萌,钟小梅,等.胆管导管内乳头状肿瘤的影像表现[J].中华放射学杂志,2014,48(2):128-131.
    [40] GUO W,ZHANG ZT. Diagnosis and treatment of intraductal papillary neoplasm of the bile duct[J]. Chin J Dig Surg,2018,17(3):233-236.(in Chinese)郭伟,张忠涛.胆管内乳头状肿瘤的诊断与治疗[J].中华消化外科杂志,2018,17(3):233-236.
    [41] YOU Y,CHOI SH,CHOI DW,et al. Recurrence after resection for intraductal papillary neoplasm of bile duct(IPNB)according to tumor location[J]. J Gastrointest Surg,2019.[Epub ahead of print]
    [42] HARADA F,MATSUYAMA R,MORI R,et al. Outcomes of surgery for 2010 WHO classification-based intraductal papillary neoplasm of the bile duct:Case-control study of a single Japanese institution’s experience with special attention to mucin expression patterns[J]. Eur J Surg Oncol,2019,45(5):761-768.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1264) PDF downloads(262) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return