Role of ghrelin and obestatin in the progression of nonalcoholic fatty liver disease

Bingbing GAO; Honghua GUO

doi:10.3969/j.issn.1001-5256.2021.05.052

Volume 37 Issue 5

May 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(5): 1221-1225

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Role of ghrelin and obestatin in the progression of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.05.052

Bingbing GAO,
Honghua GUO^,

Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun 130033, China

Received Date: 2020-09-23
Accepted Date: 2020-10-23
Published Date: 2021-05-20

Abstract

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a disease caused by multiple factors and can progress to liver cirrhosis and hepatocellular carcinoma. At present, the pathogenesis of NAFLD remains unclear and there are still no effective therapeutic drugs in clinical practice; therefore, it is particularly important to search for new therapeutic drugs that have few side effects and can effectively delay or reverse disease progression. Some studies have shown that related hormones produced by gastric tissue have a variety of effects in the regulation of energy homeostasis and obesity, and the expression level of inflammation-related genes in gastric fundus is consistent with the severity of liver disease; thus we have reason to believe that the stomach is one of the important participants in NAFLD. This article summarizes the role of ghrelin and obestatin produced by the stomach in the progression of NAFLD, which provides a new idea for the pathogenesis of NAFLD and a new direction for treatment.
- Non-Alcoholic Fatty Liver Disease,
- Ghrelin,
- Obestatin

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References(47)

References

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Role of ghrelin and obestatin in the progression of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.05.052

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Role of ghrelin and obestatin in the progression of nonalcoholic fatty liver disease

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