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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 6
Jun.  2021
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Antiviral therapy is not recommended in immune-tolerant phase chronic hepatitis B patients without complications

DOI: 10.3969/j.issn.1001-5256.2021.06.011
  • Received Date: 2021-03-23
  • Accepted Date: 2021-05-15
  • Published Date: 2021-06-20
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    FATTOVICH G, BORTOLOTTI F, DONATO F. Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors[J]. J Hepatol, 2008, 48(2): 335-352. DOI: 10.1016/j.jhep.2007.11.011.
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    ATTAR BM. CON: All patients with immune-tolerated hepatitis B virus do not need to be treated[J]. Clin Liver Dis (Hoboken), 2020, 15(1): 25-30. DOI: 10.1002/cld.893.
    [3]
    CHAN HL, CHAN CK, HUI AJ, et al. Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA[J]. Gastroenterology, 2014, 146(5): 1240-1248. DOI: 10.1053/j.gastro.2014.01.044.
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    WU ZX, CHEN FS, ZHOU XL, et al. Tenofovir and telbivudine combination therapy rapidly decreases viral loads in immune-tolerant chronic hepatitis B patients awaiting assisted reproduction: An open-label, randomized, controlled study[J]. Eur J Gastroenterol Hepatol, 2019, 31(7): 832-835. DOI: 10.1097/MEG.0000000000001345.
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    FELD JJ, TERRAULT NA, LIN HS, et al. Entecavir and peginterferon alfa-2a in adults with hepatitis B e antigen-positive immune-tolerant chronic hepatitis B virus infection[J]. Hepatology, 2019, 69(6): 2338-2348. DOI: 10.1002/hep.30417.
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    HUI CK, LEUNG N, YUEN ST, et al. Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase[J]. Hepatology, 2007, 46(2): 395-401. DOI: 10.1002/hep.21724.
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    LEE HW, KIM EH, LEE J, et al. Natural history of untreated HBeAg-positive chronic HBV infection with persistently elevated HBV DNA but normal alanine aminotransferase[J]. Clin Transl Gastroenterol, 2020, 11(3): e00140. DOI: 10.14309/ctg.0000000000000140.
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    CHEN CJ, YANG HI, SU J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level[J]. JAMA, 2006, 295(1): 65-73. DOI: 10.1001/jama.295.1.65.
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    KIM GA, LIM YS, HAN S, et al. High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B[J]. Gut, 2018, 67(5): 945-952. DOI: 10.1136/gutjnl-2017-314904.
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    ZHANG N, ZHAO YY, OU WN, et al. Analysis on the liver histology of 229 chronic hepatitis B patients with normal or slightly elevated alanine aminotransferase level[J/CD]. Chin J Exp Clin Infect Dis(Electronic Edition), 2014, 8(1): 14-17. DOI: 10.3877/cma.j.issn.1674-1358.2014.01.004.

    张娜, 赵莹莹, 欧蔚妮, 等. 肝功能正常或轻度异常的慢性HBV感染者肝组织病理改变分析[J/CD]. 中华实验和临床感染病杂志(电子版), 2014, 8(1): 14-17. DOI: 10.3877/cma.j.issn.1674-1358.2014.01.004.
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    LIAW YF, BRUNETTO MR, HADZIYANNIS S. The natural history of chronic HBV infection and geographical differences[J]. Antivir Ther, 2010, 15(Suppl 3): 25-33. DOI: 10.3851/IMP1621.
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    ANDREANI T, SERFATY L, MOHAND D, et al. Chronic hepatitis B virus carriers in the immunotolerant phase of infection: histologic findings and outcome[J]. Clin Gastroenterol Hepatol, 2007, 5(5): 636-641. DOI: 10.1016/j.cgh.2007.01.005.
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