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Volume 37 Issue 7
Jul.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(7): 1704-1707

Regulatory role of long non-coding RNAs in the development and progression of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.07.048
  • 1.

    Department of Clinical Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

  • 2.

    Department of Clinical Laboratory, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Research funding:

Luzhou Municipal People's Government & Southwest Medical University (2018LZXNYD-ZK08)

  • Received Date: 2020-12-02
  • Accepted Date: 2020-12-18
  • Published Date: 2021-07-20
    Abstract
  • Nonalcoholic fatty liver disease (NAFLD) is characterized by fatty degeneration, lipid metabolism disorders, and abnormal deposition in hepatocytes, and it has become the most prevalent liver disease in the world. The role of long non-coding RNAs (lncRNAs) in the development and progression of NAFLD has become a hotspot at present. This article summarizes the key lncRNAs in NAFLD, which are mainly involved in the regulation of the signaling pathways including lipid metabolism, glucose metabolism, and inflammatory changes, and elaborates on the mechanism of action of lncRNAs in promoting the development of NAFLD or its transformation to hepatitis and liver fibrosis. It is pointed out that in-depth on polygenomics and proteomics will promote the precise targeted therapy of NAFLD.

     

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