Role of competing endogenous RNA in the development and progression of hepatocellular carcinoma

Xiaohao CHEN; Yibin DENG

doi:10.3969/j.issn.1001-5256.2021.08.039

Volume 37 Issue 8

Aug. 2021

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Role of competing endogenous RNA in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.08.039

Xiaohao CHEN^{1, 2},
Yibin DENG^{1
,
,}

1.
Guangxi Clinical Medical Research Center for Hepatobiliary Diseases, Bose, Guangxi 533000, China
2.
Department of Laboratory Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Bose, Guangxi 533000, China

Research funding:

Natural Science Foundation of Guangxi Province (2018GXNSFAA281187)

Received Date: 2021-01-01
Accepted Date: 2021-02-09
Published Date: 2021-08-20

Abstract

Abstract

The theory of competing endogenous RNA (ceRNA) is one of the key theories in explaining gene expression regulation and biological function. This mechanism combines different RNA molecules and provides new insights into the interaction between RNAs and RNA regulatory networks. More and more studies have confirmed that ceRNA regulation plays an important role in the development and progression of tumor, most of which are mainly based on lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA regulatory networks. Studies have also shown that a variety of ceRNA regulatory networks are involved in the proliferation, invasion, and migration of tumor cells, drug resistance, angiogenesis, and tumor immunity, thus affecting tumor progression. This article elaborates on the regulatory mechanism of ceRNA, reviews the research advances in the role of ceRNA regulation in the development and progression of hepatocellular carcinoma, and discusses the ceRNA regulatory networks that play a key role in this process.
- Carcinoma, Hepatocellular,
- Competing Endogenous RNA,
- RNA, Long Noncoding

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References(40)

References

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Role of competing endogenous RNA in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.08.039

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Role of competing endogenous RNA in the development and progression of hepatocellular carcinoma

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