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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 10
Oct.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(10): 2429-2434

Role and mechanism of exosome non-coding RNA in liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2021.10.036
  • 1.

    Graduate School, Anhui University of Chinese Medicine, Hefei 230038, China

  • 2.

    Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China

  • 3.

    Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei 230038, China

Research funding:

National Natural Science Foundation of China (81973825);

National Administration of Traditional Chinese Medicine: 2019 Project of building evidence based practice capacity for TCM (2019XZZX-NB001);

Open Fund of the Key Laboratory of Xin'an Medical Education Ministry of Anhui University of Traditional Chinese Medicine (2020xayx12)

  • Received Date: 2021-03-01
  • Accepted Date: 2021-03-19
  • Published Date: 2021-10-20
    Abstract
  • Liver fibrosis is the initial stage of the development of various chronic liver diseases into liver cirrhosis and is a reversible process. As a subset of extracellular vesicles that can carry active substances such as proteins, lipids, and RNA, exosomes are involved in intercellular signal communication and have attracted more and more attention in recent years. Studies have shown that non-coding RNAs in exosomes play an important role in the development and progression of liver fibrosis. This article discusses the mechanism of action of exosome long non- coding RNAs (including MALAT1, H19, GAS5, MEG3, PVT1, and P21), exosome short non-coding RNAs (including micro-RNA, small nucleolus RNA, PIWI-interacting RNA, and small interference RNA), and exosome circular RNA in the development and progression of liver fibrosis, and it is concluded that exosomes from different sources (such as hepatocytes and cholangiocytes) carrying non-coding RNAs mainly affect the activation, proliferation, migration, and transformation of hepatic stellate cells. In-depth studies of exosome non-coding RNAs in the future are expected to find potential new targets for the treatment of liver fibrosis.

     

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